Protein tyrosine kinases in nervous system development.

Protein tyrosine kinases are important mediators of intracellular signaling during nervous system development. Activation of receptor protein tyrosine kinases by neurotrophic factors are initial events in the development of discrete cell populations. The patterns of expression and characterization of substrates for nonreceptor protein tyrosine kinases indicates that they also play a crucial role in neuronal development. The observed functional redundancy among protein tyrosine kinases and their associated intracellular signaling pathways underscores the need for further characterization of these novel interactions to elucidate the mechanisms regulating nervous system development.