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Literature DB >> 1319014

Thapsigargin blocks the induction of long-term potentiation in rat hippocampal slices.

Abstract

Experiments were performed to investigate whether intact intracellular Ca2+ pools are necessary for long-term potentiation (LTP) in the CA1 region of rat hippocampal slices. Thapsigargin (1 microM), which depletes most intracellular Ca2+ pools by blocking ATP-dependent Ca2+ uptake into intracellular compartments, blocked the induction but not the expression of LTP. Thapsigargin had no effect on synaptic transmission or on responses mediated by N-methyl-D-aspartate (NMDA) receptor activation. These data suggest that Ca2+ release from intracellular stores is required for the induction of LTP.

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Year: 1992 PMID： 1319014 DOI： 10.1016/0304-3940(92)90551-h

Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046

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Cited

30 in total

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10. Signal transduction pathways involved in the acute potentiation of NMDA responses by 1S,3R-ACPD in rat hippocampal slices.

Authors: J Harvey; G L Collingridge
Journal: Br J Pharmacol Date: 1993-08 Impact factor: 8.739

Thapsigargin blocks the induction of long-term potentiation in rat hippocampal slices.

1. Nitric oxide signaling contributes to late-phase LTP and CREB phosphorylation in the hippocampus.

2. Distinct temporal profiles of activity-dependent calcium increase in pyramidal neurons of the rat visual cortex.

Review 3. Transient receptor potential channels as novel effectors of brain-derived neurotrophic factor signaling: potential implications for Rett syndrome.

4. Serca isoform expression in the mammalian retina.

5. Age-dependent glutamate induction of synaptic plasticity in cultured hippocampal neurons.

Review 6. Understanding calcium waves and sparks in central neurons.

Review 7. Fission and fusion of the neuronal endoplasmic reticulum.

Review 8. The expression of long-term potentiation: reconciling the preists and the postivists.

9. A rise in the intracellular Ca2+ concentration of isolated rat supraoptic cells in response to oxytocin.

10. Signal transduction pathways involved in the acute potentiation of NMDA responses by 1S,3R-ACPD in rat hippocampal slices.