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Literature DB >> 131879

Islet cell membrane alteration by diabetogenic drugs.

L Orci, M Amherdt, F Malaisse-Lagae, M Ravazzola, W J Malaisse, A Perrelet, A E Renold.

Abstract

Freeze-fracture of islets of Langerhans treated in vitro with diabetogenic agents alloxan and streptozotocin shows a decrease in the number of intramembranous particles of islet cell plasma membranes. This decrease is restricted to the membrane's A-fracture face and it can be prevented by experimental conditions which are known to counteract the toxic effect of both alloxan and streptozotocin.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1976 PMID： 131879

Source DB: PubMed Journal: Lab Invest ISSN： 0023-6837 Impact factor: 5.662

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Cited

6 in total

1. Freeze-fracture analysis of intramembrane particles of erythrocytes from normal, dystrophic, and carrier mice. A possible diagnostic tool for detection of carriers of human muscular dystrophy.

Authors: R R Shivers; B G Atkinson
Journal: Am J Pathol Date: 1979-01 Impact factor: 4.307

2. Ultrastructure and membrane permeability of cultured pancreatic beta-cells exposed to alloxan or 6-hydroxydopamine.

Authors: R Norlund; K Grankvist; L Norlund; I B Täljedal
Journal: Virchows Arch A Pathol Anat Histopathol Date: 1984

3. Alloxan-induced alteration of insulin release, rubidium efflux and glucose metabolism in rat islets stimulated by various secretagogues.

Authors: J C Henquin; P Malvaux; A E Lambert
Journal: Diabetologia Date: 1979-04 Impact factor: 10.122

Islet cell membrane alteration by diabetogenic drugs.

1. Freeze-fracture analysis of intramembrane particles of erythrocytes from normal, dystrophic, and carrier mice. A possible diagnostic tool for detection of carriers of human muscular dystrophy.

2. Ultrastructure and membrane permeability of cultured pancreatic beta-cells exposed to alloxan or 6-hydroxydopamine.

3. Alloxan-induced alteration of insulin release, rubidium efflux and glucose metabolism in rat islets stimulated by various secretagogues.

4. Severe hyperglycaemia caused by autoimmunization to beta cells in rats.

5. Studies of streptozotocin-induced insulitis and diabetes.

6. Alterations in islet cell ultrastructure following streptozotocin-induced diabetes in the rat.