| Literature DB >> 1317712 |
J I Gallin1, T L Leto, D Rotrosen, C H Kwong, H L Malech.
Abstract
The phagocyte NADPH oxidase is a complex system consisting of membrane and cytosolic components that must assemble at the membrane for proper activation. Studies of patients with chronic granulomatous diseases of childhood have enabled the molecular characterization of these components, which has led to studies defining their interaction during NADPH complex assembly. Understanding NADPH oxidase assembly provides an opportunity to develop therapeutics for the regulation of this important reaction of inflammation.Entities:
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Year: 1992 PMID： 1317712 DOI： 10.1016/0952-7915(92)90124-w
Source DB: PubMed Journal: Curr Opin Immunol ISSN： 0952-7915 Impact factor: 7.486