Literature DB >> 1317508

Proteolysis, proteasomes and antigen presentation.

A L Goldberg1, K L Rock.   

Abstract

Proteins presented to the immune system must first be cleaved to small peptides by intracellular proteinases. Proteasomes are proteolytic complexes that degrade cytosolic and nuclear proteins. These particles have been implicated in ATP-ubiquitin-dependent proteolysis and in the processing of intracellular antigens for cytolytic immune responses.

Keywords:  NASA Discipline Musculoskeletal; Non-NASA Center

Mesh：

Substances：

Year:  1992        PMID： 1317508     DOI： 10.1038/357375a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  129 in total

1.  The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1.

Authors:  C M Pfleger; M W Kirschner
Journal:  Genes Dev       Date:  2000-03-15       Impact factor: 11.361

2.  c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi.

Authors:  M Wu; T J Hemesath; C M Takemoto; M A Horstmann; A G Wells; E R Price; D Z Fisher; D E Fisher
Journal:  Genes Dev       Date:  2000-02-01       Impact factor: 11.361

3.  Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S.

Authors:  G Guncar; G Pungercic; I Klemencic; V Turk; D Turk
Journal:  EMBO J       Date:  1999-02-15       Impact factor: 11.598

4.  The N terminus of microsomal delta 9 stearoyl-CoA desaturase contains the sequence determinant for its rapid degradation.

Authors:  H Mziaut; G Korza; J Ozols
Journal:  Proc Natl Acad Sci U S A       Date:  2000-08-01       Impact factor: 11.205

5.  Synthetic peptide-based activators of the proteasome.

Authors:  S Wilk; W E Chen
Journal:  Mol Biol Rep       Date:  1997-03       Impact factor: 2.316

Review 6.  Prosomes (proteasomes) changes during differentiation are related to the type of inducer.

Authors:  J P Bureau; L Henry; A Baz; K Scherrer; M T Château
Journal:  Mol Biol Rep       Date:  1997-03       Impact factor: 2.316

7.  Bile acid-induced Mallory body formation in drug-primed mouse liver.

Authors:  Peter Fickert; Michael Trauner; Andrea Fuchsbichler; Conny Stumptner; Kurt Zatloukal; Helmut Denk
Journal:  Am J Pathol       Date:  2002-12       Impact factor: 4.307

8.  Mechanism of antigen presentation after hypertonic loading of soluble antigens.

Authors:  Georg A Enders
Journal:  Immunology       Date:  2002-08       Impact factor: 7.397

9.  Metabolic acidosis stimulates muscle protein degradation by activating the adenosine triphosphate-dependent pathway involving ubiquitin and proteasomes.

Authors:  W E Mitch; R Medina; S Grieber; R C May; B K England; S R Price; J L Bailey; A L Goldberg
Journal:  J Clin Invest       Date:  1994-05       Impact factor: 14.808

10.  Sensitivity and protein turnover response to glucocorticoids are different in skeletal muscle from adult and old rats. Lack of regulation of the ubiquitin-proteasome proteolytic pathway in aging.

Authors:  D Dardevet; C Sornet; D Taillandier; I Savary; D Attaix; J Grizard
Journal:  J Clin Invest       Date:  1995-11       Impact factor: 14.808
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