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Literature DB >> 1317488

Expression of the Wilms' tumor gene (WT1) in human leukemias.

Abstract

Leukemic cells from seventy patients with various types of human leukemias were examined for expression of the WT1 gene, the Wilms' tumor gene located at chromosome 11p13. WT1 was expressed in 7 of 16 cases of acute lymphoblastic leukemia, 15 of 22 with acute myelogenous leukemia and 8 of 10 in blast crisis of chronic myelogenous leukemia. No detectable WT1 RNA was found in chronic leukemias, including chronic lymphocytic leukemia, plasma cell leukemia, hairy cell leukemia and chronic myelogenous leukemia in chronic phase. The expression pattern of WT1 in these human leukemia samples indicates the involvement of this gene in the early stage of hematological cell differentiation.

Entities: Disease Gene Species

Mesh：

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Year: 1992 PMID： 1317488

Source DB: PubMed Journal: Leukemia ISSN： 0887-6924 Impact factor: 11.528

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Cited

76 in total

Review 1. Wilms' tumor gene WT1: its oncogenic function and clinical application.

Authors: H Sugiyama
Journal: Int J Hematol Date: 2001-02 Impact factor: 2.490

Review 2. Adoptive transfer of unselected or leukemia-reactive T-cells in the treatment of relapse following allogeneic hematopoietic cell transplantation.

Authors: Richard J O'Reilly; Tao Dao; Guenther Koehne; David Scheinberg; Ekaterina Doubrovina
Journal: Semin Immunol Date: 2010-05-26 Impact factor: 11.130

Review 3. Evaluation of current cancer immunotherapy: hemato-oncology.

Authors: Christopher S Hourigan; Hyam I Levitsky
Journal: Cancer J Date: 2011 Sep-Oct Impact factor: 3.360

4. WT1 synonymous single nucleotide polymorphism rs16754 correlates with higher mRNA expression and predicts significantly improved outcome in favorable-risk pediatric acute myeloid leukemia: a report from the children's oncology group.

Authors: Phoenix A Ho; Julia Kuhn; Robert B Gerbing; Jessica A Pollard; Rong Zeng; Kristen L Miller; Nyla A Heerema; Susana C Raimondi; Betsy A Hirsch; Janet L Franklin; Beverly Lange; Alan S Gamis; Todd A Alonzo; Soheil Meshinchi
Journal: J Clin Oncol Date: 2010-12-28 Impact factor: 44.544

5. Association between WT1 polymorphisms and susceptibility to breast cancer: results from a case-control study in a southwestern Chinese population.

Authors: Xiao-Wei Qi; Xiao-Dong Zheng; Bei-Ge Zong; Qing-Qiu Chen; Fan Zhang; Xin-Hua Yang; Yi Zhang; Jun-Lan Liu; Jun Jiang
Journal: Am J Cancer Res Date: 2015-02-15 Impact factor: 6.166

6. The lck promoter-driven expression of the Wilms tumor gene WT1 blocks intrathymic differentiation of T-lineage cells.

Authors: Hanfen Li; Yoshihiro Oka; Akihiro Tsuboi; Tamotsu Yamagami; Toru Miyazaki; Sei-ichi Yusa; Kotomi Kawasaki; Yukiko Kishimoto; Momotaro Asada; Hiroko Nakajima; Keisuke Kanato; Sumiyuki Nishida; Tomoki Masuda; Masaki Murakami; Naoki Hosen; Manabu Kawakami; Hiroyasu Ogawa; Fritz Melchers; Ichiro Kawase; Yusuke Oji; Haruo Sugiyama
Journal: Int J Hematol Date: 2003-06 Impact factor: 2.490

10. Mutation or loss of Wilms' tumor gene 1 (WT1) are not major reasons for immune escape in patients with AML receiving WT1 peptide vaccination.

Authors: Antonia Busse; Anne Letsch; Carmen Scheibenbogen; Anika Nonnenmacher; Sebastian Ochsenreither; Eckhard Thiel; Ulrich Keilholz
Journal: J Transl Med Date: 2010-01-21 Impact factor: 5.531