Literature DB >> 1317454

Characterization of type V collagenase (gelatinase) in synovial fluid of patients with inflammatory arthritis.

T Hirose1, R A Reife, G N Smith, R M Stevens, C L Mainardi, K A Hasty.   

Abstract

Gelatin degrading matrix metalloproteinases in synovial fluid from 21 patients with inflammatory arthritis were shown to consist of two distinct gene products, 92 and 70 kDa gelatinases. The gelatinolytic activity of 92 kDa enzyme, which is released from stimulated neutrophils, was positively correlated to neutrophil count in the fluid. By contrast, 70 kDa molecule did not correlate with neutrophil cell count. Purification of these enzymes revealed they could degrade type XI collagen, a cartilage component resistant to interstitial collagenase. The elevated levels of 92 kDa gelatinase in rheumatoid arthritis samples compared to osteoarthritis suggest a role of this enzyme in cartilage destruction.

Entities:  

Mesh：

Substances：

Year:  1992        PMID： 1317454

Source DB:  PubMed          Journal:  J Rheumatol        ISSN： 0315-162X            Impact factor:   4.666


  8 in total

1.  pH- and temperature-dependence of functional modulation in metalloproteinases. A comparison between neutrophil collagenase and gelatinases A and B.

Authors:  G F Fasciglione; S Marini; S D'Alessio; V Politi; M Coletta
Journal:  Biophys J       Date:  2000-10       Impact factor: 4.033

2.  The collagenolytic action of MMP-1 is regulated by the interaction between the catalytic domain and the hinge region.

Authors:  Giovanni Francesco Fasciglione; Magda Gioia; Hiroki Tsukada; Jian Liang; Riccardo Iundusi; Umberto Tarantino; Massimo Coletta; Tayebeh Pourmotabbed; Stefano Marini
Journal:  J Biol Inorg Chem       Date:  2012-03-10       Impact factor: 3.358

3.  pH dependence of the enzymatic processing of collagen I by MMP-1 (fibroblast collagenase), MMP-2 (gelatinase A), and MMP-14 ectodomain.

Authors:  Magda Gioia; Giovanni Francesco Fasciglione; Susanna Monaco; Riccardo Iundusi; Diego Sbardella; Stefano Marini; Umberto Tarantino; Massimo Coletta
Journal:  J Biol Inorg Chem       Date:  2010-06-12       Impact factor: 3.358

4.  Structure-function relationship of human neutrophil collagenase: identification of regions responsible for substrate specificity and general proteinase activity.

Authors:  T Hirose; C Patterson; T Pourmotabbed; C L Mainardi; K A Hasty
Journal:  Proc Natl Acad Sci U S A       Date:  1993-04-01       Impact factor: 11.205

5.  Regulation of matrix metalloproteinase expression in human vein and microvascular endothelial cells. Effects of tumour necrosis factor alpha, interleukin 1 and phorbol ester.

Authors:  R Hanemaaijer; P Koolwijk; L le Clercq; W J de Vree; V W van Hinsbergh
Journal:  Biochem J       Date:  1993-12-15       Impact factor: 3.857

6.  The significance of altered gelatinase expression in the synovium of patient with arthritic effusions.

Authors:  Ko-Hsiu Lu; Shun-Fa Yang; Shu-Chen Chu; Pei-Ni Chen; Ming-Chih Chou; Tang-Yan Hsiao; Yih-Shou Hsieh
Journal:  Clin Rheumatol       Date:  2003-11-19       Impact factor: 2.980

7.  Neutrophil gelatinase levels in plasma and synovial fluid of patients with rheumatic diseases.

Authors:  I Sopata; J Wize; A Filipowicz-Sosnowska; E Stanisławska-Biernat; B Brzezińska; S Maśliński
Journal:  Rheumatol Int       Date:  1995       Impact factor: 2.631

8.  Collagenases and the serine proteinases elastase and cathepsin G in steroid-induced Pneumocystis carinii pneumonia.

Authors:  A Sukura; Y T Konttinen; R Sepper; L Kaartinen; T Sorsa; L A Lindberg
Journal:  J Clin Microbiol       Date:  1995-04       Impact factor: 5.948
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.