Literature DB >> 1317046

Alcohol and cocaine abuse. A comparison of epidemiology and clinical characteristics.

M H Closser1, T R Kosten.   

Abstract

Increasing numbers of persons presenting for substance abuse treatment are multiple-substance users and their predominant drugs of choice are cocaine and alcohol. There are similarities in the treatment of alcohol and cocaine abuse, but important clinical differences need to be acknowledged. This chapter compares and contrasts the most recent epidemiology and clinical characteristics of both alcohol and cocaine abusers. First, use and abuse trends in the United States for both substances are described. The clinical characteristics of dependence on either substance are contrasted in detail, and finally, treatments are briefly described. Treatment for both disorders can be accomplished in the same setting if important demographic and pharmacological differences are addressed. In either disorder, comorbid psychopathology is frequent and appropriate treatment matching based on diagnosis is imperative.

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Year:  1992        PMID: 1317046

Source DB:  PubMed          Journal:  Recent Dev Alcohol        ISSN: 0738-422X


  5 in total

Review 1.  Pharmacotherapeutics directed at deficiencies associated with cocaine dependence: focus on dopamine, norepinephrine and glutamate.

Authors:  Colin N Haile; James J Mahoney; Thomas F Newton; Richard De La Garza
Journal:  Pharmacol Ther       Date:  2012-01-31       Impact factor: 12.310

2.  Disulfiram attenuates drug-primed reinstatement of cocaine seeking via inhibition of dopamine β-hydroxylase.

Authors:  Jason P Schroeder; Debra A Cooper; Jesse R Schank; Megan A Lyle; Meriem Gaval-Cruz; Yvonne E Ogbonmwan; Nikita Pozdeyev; Kimberly G Freeman; P Michael Iuvone; Gaylen L Edwards; Philip V Holmes; David Weinshenker
Journal:  Neuropsychopharmacology       Date:  2010-08-25       Impact factor: 7.853

Review 3.  Pharmacological means of reducing human drug dependence: a selective and narrative review of the clinical literature.

Authors:  Shih-Ku Lin
Journal:  Br J Clin Pharmacol       Date:  2014-02       Impact factor: 4.335

Review 4.  mechanisms of disulfiram-induced cocaine abstinence: antabuse and cocaine relapse.

Authors:  Meriem Gaval-Cruz; David Weinshenker
Journal:  Mol Interv       Date:  2009-08

5.  Disulfiram efficacy in the treatment of alcohol dependence: a meta-analysis.

Authors:  Marilyn D Skinner; Pierre Lahmek; Héloïse Pham; Henri-Jean Aubin
Journal:  PLoS One       Date:  2014-02-10       Impact factor: 3.240

  5 in total

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