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Literature DB >> 1316876

Altered diacylglycerol level and metabolism in neutrophils from patients with localized juvenile periodontitis.

S R Tyagi¹, D J Uhlinger, J D Lambeth, C Champagne, T E Van Dyke.

Abstract

Diacylglycerol, a physiological activator of protein kinase C, was elevated nearly twofold in unstimulated peripheral blood neutrophils from patients with localized juvenile periodontitis compared with cells from normal individuals. These cells also showed an enhanced and prolonged elevation of diglyceride in response to N-formylmethionylleucylphenylalanine. The metabolism of a cell-permeant diacylglycerol by diglyceride kinase was significantly decreased, because of a fivefold or higher elevation in the apparent Km of cellular diglyceride kinase.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1992 PMID： 1316876 PMCID： PMC257185 DOI： 10.1128/iai.60.6.2481-2487.1992

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

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12 in total

1. Monocyte differentiation in localized juvenile periodontitis is skewed toward the dendritic cell phenotype.

Authors: Suzanne E Barbour; Yuichi Ishihara; Mohammed Fakher; Salma Al-Darmaki; Timothy H Caven; C P Shelburne; Al M Best; Harvey A Schenkein; John G Tew
Journal: Infect Immun Date: 2002-06 Impact factor: 3.441

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Authors: Eraldo L Batista; Alpdogan I Kantarci; Hatice Hasturk; Thomas E Van Dyke
Journal: J Periodontol Date: 2013-10-30 Impact factor: 6.993

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Authors: Tsuyoshi Fujita; Alpdogan Kantarci; Martha L Warbington; Khalid H Zawawi; Hatice Hasturk; Hidemi Kurihara; Thomas E Van Dyke
Journal: J Periodontol Date: 2005-11 Impact factor: 6.993

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Journal: J Leukoc Biol Date: 2005-06-03 Impact factor: 4.962

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Authors: Karsten Gronert; Alpdogan Kantarci; Bruce D Levy; Clary B Clish; Sabine Odparlik; Hatice Hasturk; John A Badwey; Sean P Colgan; Thomas E Van Dyke; Charles N Serhan
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Authors: Daniel Schlam; Michal Bohdanowicz; Alexandros Chatgilialoglu; Alexandros Chatilialoglu; Benjamin E Steinberg; Takehiko Ueyama; Guangwei Du; Sergio Grinstein; Gregory D Fairn
Journal: J Biol Chem Date: 2013-06-27 Impact factor: 5.157

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10. Genome-wide association study of biologically informed periodontal complex traits offers novel insights into the genetic basis of periodontal disease.

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Journal: Hum Mol Genet Date: 2016-03-08 Impact factor: 6.150