Literature DB >> 1316744

Detection of cytomegalovirus antigens in phagocytosed serum complexes from a patient with rheumatoid arthritis, vasculitis, peripheral neuropathy, cutaneous ulceration, and digital gangrene.

J N McCormick1, D Wojtacha, E Edmond.   

Abstract

A patient with rheumatoid arthritis, vasculitis, peripheral neuropathy, cutaneous ulceration, and digital gangrene was studied. Circulating immune complexes were detected by C1q binding although serum complement levels were within the normal range. Immunofluorescent staining of buffy coat cells with specific antisera showed the presence of IgG and IgM in phagocytosed inclusions but complement C3 was not detected. A monoclonal antibody specific for cytomegalovirus detected antigens in phagocytosed inclusions on one occasion. These results may suggest that cytomegalovirus antigens are a hitherto unidentified component of serum complexes in patients with rheumatoid arthritis and may contribute to the pathogenesis of the vasculitic complications of rheumatoid arthritis by participating in immune complex formation.

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Year:  1992        PMID： 1316744      PMCID： PMC1004715          DOI： 10.1136/ard.51.4.553

Source DB:  PubMed          Journal:  Ann Rheum Dis        ISSN： 0003-4967            Impact factor:   19.103


  10 in total

1.  Perivascular deposits of IgM in the skin of transplant recipients during active cytomegalovirus infections. Correlation with IgM rheumatoid factors and IgM immune complexes.

Authors:  W M Baldwin; M L Westedt; B J Vermeer; J J Weening; G W van Gemert; B W Boom; L C Paul; M R Daha; L A van Es
Journal:  Transplantation       Date:  1987-10       Impact factor: 4.939

2.  Acute monoarticular arthritis caused by herpes simplex virus and cytomegalovirus.

Authors:  H M Friedman; T Pincus; P Gibilisco; D Baker; J P Glazer; S A Plotkin; H R Schumacher
Journal:  Am J Med       Date:  1980-08       Impact factor: 4.965

3.  Immune-complex glomerulonephritis associated with cytomegalovirus infection.

Authors:  T Ozawa; J A Stewart
Journal:  Am J Clin Pathol       Date:  1979-07       Impact factor: 2.493

4.  The association of cryoglobulinaemia with nodules, vasculitis and fibrosing alveolitis in rheumatoid arthritis and their relationship to serum C1q binding activity and rheumatoid factor.

Authors:  C C Erhardt; P Mumford; R N Maini
Journal:  Clin Exp Immunol       Date:  1979-12       Impact factor: 4.330

5.  Increased IgM and IgM immune complex-like material in the circulation of renal transplant recipients with primary cytomegalovirus infections.

Authors:  W M Baldwin; A van Es; R M Valentijn; G W van Gemert; M R Daha; L A Vanes
Journal:  Clin Exp Immunol       Date:  1982-12       Impact factor: 4.330

6.  Clinical and serological features of severe vasculitis in rheumatoid arthritis: prognostic implications.

Authors:  A J Geirsson; G Sturfelt; L Truedsson
Journal:  Ann Rheum Dis       Date:  1987-10       Impact factor: 19.103

7.  Immune complexes in congenital and natal cytomegalovirus infections of man.

Authors:  S Stagno; J E Volanakis; D W Reynolds; R Stroud; C A Alford
Journal:  J Clin Invest       Date:  1977-10       Impact factor: 14.808

8.  The complement fixing ability of putative circulating immune complexes in rheumatoid arthritis and its relationship to extra-articular disease.

Authors:  B E Bourke; I K Moss; P Mumford; A Horsfall; R N Maini
Journal:  Clin Exp Immunol       Date:  1982-06       Impact factor: 4.330

9.  High levels of cytomegalovirus antibody in patients requiring vascular surgery for atherosclerosis.

Authors:  E Adam; J L Melnick; J L Probtsfield; B L Petrie; J Burek; K R Bailey; C H McCollum; M E DeBakey
Journal:  Lancet       Date:  1987-08-08       Impact factor: 79.321

10.  Demonstration of an unidentified 48 kD polypeptide in circulating immune complexes in rheumatoid arthritis.

Authors:  R D Melsom; P R Smith; R N Maini
Journal:  Ann Rheum Dis       Date:  1987-02       Impact factor: 19.103
  10 in total
  2 in total

1.  Phantom cytomegalovirus infection in vasculitis patients: what it means and what to do.

Authors:  Konstantinos H Katsanos; Aggeliki Kostoula; Konstantinos P Katopodis; Kostas C Siamopoulos
Journal:  Rheumatol Int       Date:  2004-10-16       Impact factor: 2.631

2.  Correlative studies of rheumatoid factors and anti-viral antibodies in patients with rheumatoid arthritis.

Authors:  A S Ferraro; M M Newkirk
Journal:  Clin Exp Immunol       Date:  1993-06       Impact factor: 4.330
  2 in total

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