| Literature DB >> 1316094 |
Abstract
Chronic granulomatous disease (CGD) encompasses a group of rare inherited disorders characterized by defects in a phagocyte-specific NADPH-oxidase complex that forms the superoxide radical during the respiratory burst. In this chapter, the protein components and cellular biochemistry of the oxidase are reviewed in light of recent genetic and biochemical studies of CGD. The classification and molecular genetic analysis of CGD is discussed. Finally, the use of recombinant human interferon-gamma as a new therapeutic agent for management of the disorder is reviewed.Entities:
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Year: 1992 PMID： 1316094 DOI： 10.1146/annurev.me.43.020192.001001
Source DB: PubMed Journal: Annu Rev Med ISSN： 0066-4219 Impact factor: 13.739