Literature DB >> 1315975

Diazepam antagonizes effects on dopamine metabolism produced by PCP receptor agonists.

M B Bowers1, J B Morton.   

Abstract

1. Male rats were injected with either saline, diazepam, MK-801, or diazepam plus MK-801. 2. In previous work with phencyclidine (PCP), diazepam significantly reduced the increase in homovanillic acid (HVA) in olfactory tubercle and prefrontal cortex. 3. Diazepam also lowered the HVA increase following MK-801 in caudate, olfactory tubercle, and prefrontal cortex. 4. Benzodiazepine receptors may modify dopaminergic function at PCP receptors that affect dopamine neurotransmission.

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Year:  1992        PMID： 1315975     DOI： 10.1016/0278-5846(92)90072-m

Source DB:  PubMed          Journal:  Prog Neuropsychopharmacol Biol Psychiatry        ISSN： 0278-5846            Impact factor:   5.067


  3 in total

1.  Phencyclidine increases forebrain monoamine metabolism in rats and monkeys: modulation by the isomers of HA966.

Authors:  J D Jentsch; J D Elsworth; D E Redmond; R H Roth
Journal:  J Neurosci       Date:  1997-03-01       Impact factor: 6.167

2.  Effects of acute lorazepam administration on aminergic activity in normal elderly subjects: relationship to performance effects and apolipoprotein genotype.

Authors:  Nunzio Pomara; Lisa M Willoughby; Audrey Hashim; Henry Sershen; John J Sidtis; Keith Wesnes; David J Greenblatt; Abel Lajtha
Journal:  Neurochem Res       Date:  2004-07       Impact factor: 3.996

3.  Clonidine and guanfacine attenuate phencyclidine-induced dopamine overflow in rat prefrontal cortex: mediating influence of the alpha-2A adrenoceptor subtype.

Authors:  J David Jentsch; Diana Sanchez; John D Elsworth; Robert H Roth
Journal:  Brain Res       Date:  2008-10-18       Impact factor: 3.252
  3 in total

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