| Literature DB >> 1315725 |
H Minn1, L Kangas, P Kellokumpu-Lehtinen, P Klemi, H Sipilä, J Vuorinen, P Härkönen, M Lähde.
Abstract
Mice bearing intramuscular Lewis lung tumor were treated with BCNU and doxorubicin (ADM) to study chemotherapy-induced changes in the uptake of 2-fluoro-2-deoxy-[U-14C]glucose (FDG). A decreased FDG uptake, tumor regression and a diminished proportion of aneuploid versus diploid cells as evaluated by DNA flow cytometry were seen after treatment with BCNU but not with ADM; HPLC indicated that most of the 14C activity in tumors was from FDG6-phosphate. The results suggest that changes in FDG uptake reflect the effectiveness of antitumor therapy. FDG may be valuable in follow-up studies of cancer treatment.Entities:
Mesh：
Substances：
Year: 1992 PMID： 1315725 DOI： 10.1016/0883-2897(92)90185-2
Source DB: PubMed Journal: Int J Rad Appl Instrum B ISSN： 0883-2897