Literature DB >> 1315535

Sugar modified oligonucleotides: synthesis, nuclease resistance and base pairing of oligodeoxynucleotides containing 1-(4'-thio-beta-D-ribofuranosyl)-thymine.

L Bellon1, F Morvan, J L Barascut, J L Imbach.   

Abstract

XdT12 and dT5XdT6, where X is 1-(4'-thio-beta-d-ribofuranosyl)-thymine, were synthesized. The first oligonucleotide presents a better stability against calf spleen phosphodiesterase than natural dT12. The second one hybridizes with complementary sequence. However the X:A base pairing stability is lower than natural T:A one.

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Year:  1992        PMID： 1315535     DOI： 10.1016/0006-291x(92)90660-d

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  3 in total

1.  4'-Thio-oligo-beta-D-ribonucleotides: synthesis of beta-4'-thio-oligouridylates, nuclease resistance, base pairing properties, and interaction with HIV-1 reverse transcriptase.

Authors:  L Bellon; J L Barascut; G Maury; G Divita; R Goody; J L Imbach
Journal:  Nucleic Acids Res       Date:  1993-04-11       Impact factor: 16.971

2.  Investigation of some properties of oligodeoxynucleotides containing 4'-thio-2'-deoxynucleotides: duplex hybridization and nuclease sensitivity.

Authors:  G D Jones; E A Lesnik; S R Owens; L M Risen; R T Walker
Journal:  Nucleic Acids Res       Date:  1996-11-01       Impact factor: 16.971

Review 3.  The role of the 5' untranslated region of eukaryotic messenger RNAs in translation and its investigation using antisense technologies.

Authors:  K Pantopoulos; H E Johansson; M W Hentze
Journal:  Prog Nucleic Acid Res Mol Biol       Date:  1994
  3 in total

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