| Literature DB >> 1315393 |
C Hubschwerlen1, P Pflieger, J L Specklin, K Gubernator, H Gmünder, P Angehrn, I Kompis.
Abstract
Substituted 4-quinolone- (1, A = CH) and 1,8-naphthyrid-4-one- (1, A = N) 3-carboxylic acids are currently the only classes of clinically useful antibacterial agents exerting their activity by inhibiting the subunit A of DNA gyrase. Pyrimido[1,6-alpha]benzimidazoles 11 have been found to be a new class of inhibitors of this enzyme. The design, synthesis, and biological activity of these compounds are reported.Entities:
Mesh：
Substances：
Year: 1992 PMID： 1315393 DOI： 10.1021/jm00086a006
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446