| Literature DB >> 1314578 |
E Mita1, N Hayashi, K Ueda, A Kasahara, H Fusamoto, A Takamizawa, K Matsubara, H Okayama, T Kamada.
Abstract
To characterize the putative NS1/E2 (non-structural protein 1/envelope 2) domain of HCV (hepatitis C virus), we expressed the hydrophilic three-quarters of this domain in a form of MBP (maltose binding protein) fusions in Escherichia coli. When we checked the positive frequency of antibody to this fusion protein, 17% of patients with type C chronic liver disease had this antibody. However, they were all positive for HCV-RNA in sera. These results suggest that the appearance of anti-NS1/E2 antibody does not serve as evidence of viral clearance.Entities:
Mesh：
Substances：
Year: 1992 PMID： 1314578 DOI： 10.1016/s0006-291x(05)80278-5
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575