| Literature DB >> 1314454 |
B A Israel1, R Herber, Y Gao, G J Letchworth.
Abstract
Current vaccines for human and animal herpesviruses engender an immunity that may ameliorate disease but generally fails to prevent infection, latency, reactivation from latency, or spread through a population. By administering intranasally to cattle bovine herpesvirus type 1 virion envelope proteins combined with the potent mucosal immune system adjuvant, cholera toxin B subunit, we engendered a local antibody response that acted as a barrier to infection of mucosal epithelial cells and thereby prevented viral replication, consequently precluding disease, latency, and spread.Entities:
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Year: 1992 PMID： 1314454 DOI： 10.1016/0042-6822(92)90755-e
Source DB: PubMed Journal: Virology ISSN： 0042-6822 Impact factor: 3.616