Literature DB >> 1314426

Calcium-regulated phosphorylation within the leucine zipper of C/EBP beta.

M Wegner1, Z Cao, M G Rosenfeld.   

Abstract

Alterations in intracellular calcium levels activate several signal transduction pathways resulting in distinct patterns of gene expression. Here, a pathway for calcium-mediated signals is demonstrated that involves C/EBP beta, a member of the bZip family of transcription factors. In pituitary cells C/EBP beta was phosphorylated in response to increased intracellular calcium concentrations as a consequence of the activation of a calcium-calmodulin-dependent protein kinase. Phosphorylation of serine at position 276 within the leucine zipper of C/EBP beta appeared to confer calcium-regulated transcriptional stimulation of a promoter that contained binding sites for C/EBP beta.

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Year:  1992        PMID： 1314426     DOI： 10.1126/science.256.5055.370

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  90 in total

1.  Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element.

Authors:  M Ubeda; X Z Wang; H Zinszner; I Wu; J F Habener; D Ron
Journal:  Mol Cell Biol       Date:  1996-04       Impact factor: 4.272

2.  Interaction of the co-activator CBP with Myb proteins: effects on Myb-specific transactivation and on the cooperativity with NF-M.

Authors:  M Oelgeschläger; R Janknecht; J Krieg; S Schreek; B Lüscher
Journal:  EMBO J       Date:  1996-06-03       Impact factor: 11.598

3.  A novel transcriptional regulatory region within the core promoter of the hepatocyte growth factor gene is responsible for its inducibility by cytokines via the C/EBP family of transcription factors.

Authors:  J G Jiang; R Zarnegar
Journal:  Mol Cell Biol       Date:  1997-10       Impact factor: 4.272

4.  Regulation of C/EBPbeta isoforms by MAPK pathways in HL60 cells induced to differentiate by 1,25-dihydroxyvitamin D3.

Authors:  Ewa Marcinkowska; Edward Garay; Elzbieta Gocek; Agnieszka Chrobak; Xuening Wang; George P Studzinski
Journal:  Exp Cell Res       Date:  2006-04-19       Impact factor: 3.905

5.  Calcium/calmodulin-dependent protein kinase II regulates cyclooxygenase-2 expression and prostaglandin E2 production by activating cAMP-response element-binding protein in rat peritoneal macrophages.

Authors:  Xueyuan Zhou; Junying Li; Wenxiu Yang
Journal:  Immunology       Date:  2014-10       Impact factor: 7.397

6.  Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family.

Authors:  D E Clevidence; D G Overdier; W Tao; X Qian; L Pani; E Lai; R H Costa
Journal:  Proc Natl Acad Sci U S A       Date:  1993-05-01       Impact factor: 11.205

7.  CCAAT enhancer- binding protein beta is required for normal hepatocyte proliferation in mice after partial hepatectomy.

Authors:  L E Greenbaum; W Li; D E Cressman; Y Peng; G Ciliberto; V Poli; R Taub
Journal:  J Clin Invest       Date:  1998-09-01       Impact factor: 14.808

8.  Source of nuclear calcium signals.

Authors:  N L Allbritton; E Oancea; M A Kuhn; T Meyer
Journal:  Proc Natl Acad Sci U S A       Date:  1994-12-20       Impact factor: 11.205

9.  C/EBPbeta regulation in lipopolysaccharide-stimulated macrophages.

Authors:  Michelle N Bradley; Liang Zhou; Stephen T Smale
Journal:  Mol Cell Biol       Date:  2003-07       Impact factor: 4.272

Review 10.  Role of mitogen-activated protein kinases and protein kinase C in regulating low-density lipoprotein receptor expression.

Authors:  Kamal D Mehta
Journal:  Gene Expr       Date:  2002
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