Literature DB >> 1314321

Hepatocellular carcinoma in a case of Wilson's disease.

W S Cheng1, S Govindarajan, A G Redeker.   

Abstract

Hepatocellular carcinoma has rarely been reported in Wilson's disease, particularly in women. We describe the case of a female patient who was diagnosed with Wilson's disease at the age of 39 years, after presenting with severe neurological symptoms. She had significant neurological improvement following penicillamine therapy and succumbed to hepatocellular carcinoma at the age of 72 years, following 33 years of penicillamine therapy. The patient described here was the oldest and only the third female patient with hepatocellular carcinoma complicating Wilson's disease to be reported in the literature.

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Year:  1992        PMID: 1314321     DOI: 10.1111/j.1600-0676.1992.tb00553.x

Source DB:  PubMed          Journal:  Liver        ISSN: 0106-9543


  12 in total

1.  Consequences of copper accumulation in the livers of the Atp7b-/- (Wilson disease gene) knockout mice.

Authors:  Dominik Huster; Milton J Finegold; Clinton T Morgan; Jason L Burkhead; Randal Nixon; Scott M Vanderwerf; Conrad T Gilliam; Svetlana Lutsenko
Journal:  Am J Pathol       Date:  2006-02       Impact factor: 4.307

2.  Wilson disease and hepatocellular carcinoma.

Authors:  Ruliang Xu; Cristina H Hajdu
Journal:  Gastroenterol Hepatol (N Y)       Date:  2008-06

Review 3.  Molecular imaging and therapy targeting copper metabolism in hepatocellular carcinoma.

Authors:  Jason Wachsmann; Fangyu Peng
Journal:  World J Gastroenterol       Date:  2016-01-07       Impact factor: 5.742

4.  Increased p53 mutation load in nontumorous human liver of wilson disease and hemochromatosis: oxyradical overload diseases.

Authors:  S P Hussain; K Raja; P A Amstad; M Sawyer; L J Trudel; G N Wogan; L J Hofseth; P G Shields; T R Billiar; C Trautwein; T Hohler; P R Galle; D H Phillips; R Markin; A J Marrogi; C C Harris
Journal:  Proc Natl Acad Sci U S A       Date:  2000-11-07       Impact factor: 11.205

5.  Plasma Level of Interleukin-35 as an Independent Prognostic Indicator in Hepatocellular Carcinoma.

Authors:  Xiangting Qiu; Xinhua Wang; Yucui Song; Lingling Chen
Journal:  Dig Dis Sci       Date:  2016-10-03       Impact factor: 3.199

6.  Hepatocellular carcinoma in a non-cirrhotic patient with Wilson's disease.

Authors:  Raphael Thattil; Jean-François Dufour
Journal:  World J Gastroenterol       Date:  2013-04-07       Impact factor: 5.742

Review 7.  Wilson disease.

Authors:  Cord Langner; Helmut Denk
Journal:  Virchows Arch       Date:  2004-06-17       Impact factor: 4.064

Review 8.  Non-viral causes of hepatocellular carcinoma.

Authors:  David H Van Thiel; Guiliano Ramadori
Journal:  J Gastrointest Cancer       Date:  2011-12

9.  Animal models of copper-associated liver disease.

Authors:  I Carmen Fuentealba; Enrique M Aburto
Journal:  Comp Hepatol       Date:  2003-04-03

10.  A Case of Colonic Adenocarcinoma in a Patient with Wilson's Disease.

Authors:  Sang Youn Lee; In Hee Kim; Sun Ho Yoo; Dae-Ghon Kim
Journal:  Gut Liver       Date:  2013-07-11       Impact factor: 4.519

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