| Literature DB >> 1314190 |
M A Versnel1, M J Bouts, A W Langerak, T H van der Kwast, H C Hoogsteden, A Hagemeijer, C H Heldin.
Abstract
The effect of hydrocortisone (HC) on PDGF beta-receptor expression was studied in the human malignant mesothelioma cell line Mero-14. HC was found to induce a time- and dose-dependent increase of PDGF beta-receptor mRNA. Nuclear run off analysis revealed that HC induced increased transcription of the PDGF beta-receptor gene. The expression of PDGF beta-receptor protein was also elevated by HC as demonstrated with an immunoblotting assay. However, the number of PDGF-BB binding sites on the cell surface of Mero-14 remained unchanged upon HC treatment. These results suggest that steroid hormones can regulate PDGF receptor expression in vivo.Entities:
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Year: 1992 PMID： 1314190 DOI： 10.1016/s0014-4827(05)80074-6
Source DB: PubMed Journal: Exp Cell Res ISSN： 0014-4827 Impact factor: 3.905