| Literature DB >> 1313876 |
R W Harper1, D K Herron, N G Bollinger, J S Sawyer, R F Baldwin, C R Roman, L E Rinkema, J H Fleisch.
Abstract
A hypothetical model for receptor binding of leukotriene D4 (LTD4) was deduced from conformational analysis of LTD4 and from the structure-activity relationships (SAR) of known LTD4 receptor antagonists. A new structural series of LTD4 receptor antagonists exemplified by 5-[4-(4-phenylbutoxy)phenyl]-2-[4-(tetrazol-5-yl)butyl]-2H-t etrazole was designed in which a phenyltetrazole moiety was incorporated as a receptor binding equivalent of the triene unit of LTD4. A number of these phenyltetrazoles were prepared and found to possess LTD4 receptor antagonist activity. The structure-activity relationship (SAR) of this series is described.Entities:
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Year: 1992 PMID： 1313876 DOI： 10.1021/jm00085a004
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446