Literature DB >> 13136

Lathyritic activity of isoniazid.

A J Arem, R Misiorowski.   

Abstract

Although isoniazid is mainly known and used for its antituberculous properties, it is also a lathyrogenic agent. This paper presents data confirming the lathyritic activity of isoniazid in vitro and in vivo and suggests that its action on connective tissue may be partly responsible for its therapeutic effectiveness.

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Year:  1976        PMID: 13136

Source DB:  PubMed          Journal:  J Med        ISSN: 0025-7850


  4 in total

1.  Evidence for the role of vitamin C-6 as a cofactor of lysyl oxidase.

Authors:  J C Murray; C I Levene
Journal:  Biochem J       Date:  1977-11-01       Impact factor: 3.857

2.  The inhibition of lysyl oxidase in vivo by isoniazid and its reversal by pyridoxal. Effect on collagen cross-linking in the chick embryo.

Authors:  M J Carrington; T A Bird; C I Levene
Journal:  Biochem J       Date:  1984-08-01       Impact factor: 3.857

3.  The effect of a vitamin B-6 antagonist, 4-deoxypyridoxine, on the cross-linking of collagen in the developing chick embryo.

Authors:  T A Bird; C I Levene
Journal:  Biochem J       Date:  1983-03-15       Impact factor: 3.857

4.  Reactivity of a functional carbonyl moiety in bovine aortic lysyl oxidase. Evidence against pyridoxal 5'-phosphate.

Authors:  P R Williamson; J M Kittler; J W Thanassi; H M Kagan
Journal:  Biochem J       Date:  1986-04-15       Impact factor: 3.857

  4 in total

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