BACKGROUND: The effect of familial loading on neurocognitive deficits in relatives of schizophrenia patients has been detected in family and twin studies. The present study examined this effect among healthy siblings of schizophrenia patients in a Finnish isolate with high prevalence of schizophrenia. METHODS: We assessed performance in verbal and visual span tasks, in tests measuring intelligence, and in declarative verbal memory and learning tasks in 31 and 67 healthy siblings from families with one schizophrenia patient, or with two or more patients, respectively. The differences between the groups were tested using linear mixed effects models. RESULTS: An effect of familial loading was detected in the backward visual span task, measuring immediate visual memory with requirements from the visual domain of working memory. In this task, the healthy siblings from multiply affected families performed worse than those from the singleton families. CONCLUSIONS: The finding that the multiplex vs. singleton differences were selective to the backward visual span task, strengthens the view that the visual domain of working memory may provide a valuable endophenotypic marker for genetic schizophrenia studies.
BACKGROUND: The effect of familial loading on neurocognitive deficits in relatives of schizophreniapatients has been detected in family and twin studies. The present study examined this effect among healthy siblings of schizophreniapatients in a Finnish isolate with high prevalence of schizophrenia. METHODS: We assessed performance in verbal and visual span tasks, in tests measuring intelligence, and in declarative verbal memory and learning tasks in 31 and 67 healthy siblings from families with one schizophreniapatient, or with two or more patients, respectively. The differences between the groups were tested using linear mixed effects models. RESULTS: An effect of familial loading was detected in the backward visual span task, measuring immediate visual memory with requirements from the visual domain of working memory. In this task, the healthy siblings from multiply affected families performed worse than those from the singleton families. CONCLUSIONS: The finding that the multiplex vs. singleton differences were selective to the backward visual span task, strengthens the view that the visual domain of working memory may provide a valuable endophenotypic marker for genetic schizophrenia studies.
Authors: Silvia Scala; Andrea Pousada; William S Stone; Heidi W Thermenos; Theo C Manschreck; Ming T Tsuang; Stephen V Faraone; Larry J Seidman Journal: Schizophr Res Date: 2013-01-09 Impact factor: 4.939
Authors: William P Horan; David L Braff; Keith H Nuechterlein; Catherine A Sugar; Kristin S Cadenhead; Monica E Calkins; Dorcas J Dobie; Robert Freedman; Tiffany A Greenwood; Raquel E Gur; Ruben C Gur; Gregory A Light; James Mintz; Ann Olincy; Allan D Radant; Nicholas J Schork; Larry J Seidman; Larry J Siever; Jeremy M Silverman; William S Stone; Neal R Swerdlow; Debbie W Tsuang; Ming T Tsuang; Bruce I Turetsky; Michael F Green Journal: Schizophr Res Date: 2008-04-11 Impact factor: 4.939
Authors: Pramod Thomas; Fanyin He; Sati Mazumdar; Joel Wood; Triptish Bhatia; Ruben C Gur; Raquel E Gur; Daniel Buysse; Vishwajit L Nimgaonkar; Smita N Deshpande Journal: Asian J Psychiatr Date: 2017-11-07