Literature DB >> 13129567

The discovery of BMS-275183: an orally efficacious novel taxane.

Harold Mastalerz1, Donald Cook, Craig R Fairchild, Steven Hansel, Walter Johnson, John F Kadow, Byron H Long, William C Rose, James Tarrant, Mu-Jen Wu, May Quifen Xue, Guifen Zhang, Mary Zoeckler, Dolatrai M Vyas.   

Abstract

The evolution of 2, a C-4-methylcarbonate analogue of paclitaxel with minimal oral bioavailability and oral efficacy, into its C-3'-t-butyl-3'-N-t-butyloxycarbonyl analogue (15i), a novel taxane with oral efficacy in preclinical models that is comparable to iv administered paclitaxel, is described.

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Year:  2003        PMID： 13129567     DOI： 10.1016/s0968-0896(03)00495-4

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  9 in total

1.  Synthesis of docetaxel and butitaxel analogues through kinetic resolution of racemic beta-lactams with 7-O-triethylsilylbaccatin III.

Authors:  Haibo Ge; Jared T Spletstoser; Yan Yang; Margaret Kayser; Gunda I Georg
Journal:  J Org Chem       Date:  2007-02-02       Impact factor: 4.354

2.  A phase 1 study of BMS-275183, a novel oral analogue of paclitaxel given on a daily schedule to patients with advanced malignancies.

Authors:  Elisabeth I Heath; Patricia Lorusso; Suresh S Ramalingam; Ahmad Awada; Merrill J Egorin; Tatiana Besse-Hamer; Fatima Cardoso; Manuel Valdivieso; Teresa Has; Leila Alland; Xiaofei Zhou; Chandra P Belani
Journal:  Invest New Drugs       Date:  2010-08-03       Impact factor: 3.850

Review 3.  Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies.

Authors:  Carlo Ballatore; Kurt R Brunden; Donna M Huryn; John Q Trojanowski; Virginia M-Y Lee; Amos B Smith
Journal:  J Med Chem       Date:  2012-09-28       Impact factor: 7.446

4.  Novel oral taxane therapies: recent Phase I results.

Authors:  John Paul Flores; M Wasif Saif
Journal:  Clin Investig (Lond)       Date:  2013

Review 5.  Clinical pharmacokinetics of docetaxel : recent developments.

Authors:  Sharyn D Baker; Alex Sparreboom; Jaap Verweij
Journal:  Clin Pharmacokinet       Date:  2006       Impact factor: 6.447

Review 6.  Targeting microtubules by natural agents for cancer therapy.

Authors:  Eiman Mukhtar; Vaqar Mustafa Adhami; Hasan Mukhtar
Journal:  Mol Cancer Ther       Date:  2014-01-16       Impact factor: 6.261

7.  Synthesis, tubulin assembly, and antiproliferative activity against MCF7 and NCI/ADR-RES cancer cells of 10-O-acetyl-5'-hydroxybutitaxel.

Authors:  Haibo Ge; Jianmei Wang; Margaret M Kayser; Richard H Himes; Gunda I Georg
Journal:  Bioorg Med Chem Lett       Date:  2008-10-07       Impact factor: 2.823

8.  "Effect of the drug transporters ABCB1, ABCC2, and ABCG2 on the disposition and brain accumulation of the taxane analog BMS-275,183".

Authors:  Serena Marchetti; Dick Pluim; Jos H Beijnen; Roberto Mazzanti; Olaf van Tellingen; Jan H M Schellens
Journal:  Invest New Drugs       Date:  2014-07-31       Impact factor: 3.850

Review 9.  Microtubule-Interfering Drugs: Current and Future Roles in Epithelial Ovarian Cancer Treatment.

Authors:  Joan Tymon-Rosario; Naomi N Adjei; Dana M Roque; Alessandro D Santin
Journal:  Cancers (Basel)       Date:  2021-12-12       Impact factor: 6.639
  9 in total

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