Literature DB >> 1312948

Bestatin inhibits covalent coupling of [3H]LTA4 to human leukocyte LTA4 hydrolase.

J F Evans1, S Kargman.   

Abstract

The covalent coupling of [3H]LTA4 to human leukocyte LTA4 hydrolase is inhibited in a concentration-dependent fashion by pre-incubation with bestatin. This inhibition correlated with the concentration-dependent inhibition by bestatin of LTB4 and LTB5 synthesis by LTA4 hydrolase. Epibestatin, a diastereomer of bestatin, neither inhibited LTB4 or LTB5 production by LTA4 hydrolase nor prevented the covalent coupling of [3H]LTA4 to the enzyme. In contrast, captopril inhibited both LTB4 synthesis by LTA4 hydrolase and covalent coupling of [3H]LTA4 to the enzyme.

Entities:  

Mesh：

Substances：

Year:  1992        PMID： 1312948     DOI： 10.1016/0014-5793(92)80345-h

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  6 in total

1.  Leukotriene A4 hydrolase: protection from mechanism-based inactivation by mutation of tyrosine-378.

Authors:  M J Mueller; M Blomster; U C Oppermann; H Jörnvall; B Samuelsson; J Z Haeggström
Journal:  Proc Natl Acad Sci U S A       Date:  1996-06-11       Impact factor: 11.205

2.  The cytotoxic activity of Bacillus anthracis lethal factor is inhibited by leukotriene A4 hydrolase and metallopeptidase inhibitors.

Authors:  A Menard; E Papini; M Mock; C Montecucco
Journal:  Biochem J       Date:  1996-12-01       Impact factor: 3.857

3.  Leukotriene A4 hydrolase: mapping of a henicosapeptide involved in mechanism-based inactivation.

Authors:  M J Mueller; A Wetterholm; M Blomster; H Jörnvall; B Samuelsson; J Z Haeggström
Journal:  Proc Natl Acad Sci U S A       Date:  1995-08-29       Impact factor: 11.205

4.  The aminopeptidase activity in the human T-cell lymphoma line (Jurkat) is not at the cell surface and is not aminopeptidase N (CD-13).

Authors:  H Murray; A J Turner; A J Kenny
Journal:  Biochem J       Date:  1994-03-01       Impact factor: 3.857

Review 5.  Metallo-aminopeptidase inhibitors.

Authors:  Artur Mucha; Marcin Drag; John P Dalton; Paweł Kafarski
Journal:  Biochimie       Date:  2010-05-10       Impact factor: 4.079

Review 6.  Aminopeptidase-N/CD13 (EC 3.4.11.2) inhibitors: chemistry, biological evaluations, and therapeutic prospects.

Authors:  Brigitte Bauvois; Daniel Dauzonne
Journal:  Med Res Rev       Date:  2006-01       Impact factor: 12.944
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.