| Literature DB >> 1312905 |
M Miyazaki1, E Gohda, S Tsuboi, H Tsubouchi, Y Daikuhara, M Namba, I Yamamoto.
Abstract
The effects of human hepatocyte growth factor (hHGF), a potent mitogen for rat and human hepatocytes in primary culture, on proliferation of human hepatoma and hepatoblastoma cells were examined. Out of five cell lines; HLE, HuH-6 clone 5, HuH-7, PLC/PRF/5, and Hep G2, only HuH-6 Clone 5 cells were stimulated by recombinant hHGF. Both native and recombinant hHGFs caused dose-dependent increases in cell number and DNA synthesis of cells. This stimulation was strongly inhibited by anti-hHGF monoclonal antibody.Entities:
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Year: 1992 PMID： 1312905 DOI： 10.1016/s0309-1651(06)80108-6
Source DB: PubMed Journal: Cell Biol Int Rep ISSN： 0309-1651