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Literature DB >> 1312615

Inhibition of poliovirus RNA synthesis by brefeldin A.

L A Maynell¹, K Kirkegaard, M W Klymkowsky.

Abstract

Brefeldin A (BFA), a fungal metabolite that blocks transport of newly synthesized proteins from the endoplasmic reticulum, was found to inhibit poliovirus replication 10(5)- to 10(6)-fold. BFA does not inhibit entry of poliovirus into the cell or translation of viral RNA. Poliovirus RNA synthesis, however, is completely inhibited by BFA. A specific class of membranous vesicles, with which the poliovirus replication complex is physically associated, is known to proliferate in poliovirus-infected cells. BFA may inhibit poliovirus replication by preventing the formation of these vesicles.

Entities: Chemical Species

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Year: 1992 PMID： 1312615 PMCID： PMC288987

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

43 in total

Review 1. Regulation of translation by poliovirus.

Authors: N Sonenberg
Journal: Adv Virus Res Date: 1987 Impact factor: 9.937

2. Proteolysis of the p220 component of the cap-binding protein complex is not sufficient for complete inhibition of host cell protein synthesis after poliovirus infection.

Authors: A M Bonneau; N Sonenberg
Journal: J Virol Date: 1987-04 Impact factor: 5.103

3. Characterization of poliovirus-specific structures associated with cytoplasmic membranes.

Authors: L A Caliguiri; I Tamm
Journal: Virology Date: 1970-09 Impact factor: 3.616

4. Virus replication, cytopathology, and lysosomal enzyme response of mitotic and interphase Hep-2 cells infected with poliovirus.

Authors: K Bienz; D Egger; D A Wolff
Journal: J Virol Date: 1973-04 Impact factor: 5.103

5. Antiviral activity of brefeldin A and verrucarin A.

Authors: G Tamura; K Ando; S Suzuki; A Takatsuki; K Arima
Journal: J Antibiot (Tokyo) Date: 1968-02 Impact factor: 2.649

6. Kinetics and location of poliovirus macromolecular synthesis in correlation to virus-induced cytopathology.

Authors: K Bienz; D Egger; Y Rasser; W Bossart
Journal: Virology Date: 1980-01-30 Impact factor: 3.616

7. Poliovirus mutant that does not selectively inhibit host cell protein synthesis.

Authors: H D Bernstein; N Sonenberg; D Baltimore
Journal: Mol Cell Biol Date: 1985-11 Impact factor: 4.272

8. Translation of glucose-regulated protein 78/immunoglobulin heavy-chain binding protein mRNA is increased in poliovirus-infected cells at a time when cap-dependent translation of cellular mRNAs is inhibited.

Authors: P Sarnow
Journal: Proc Natl Acad Sci U S A Date: 1989-08 Impact factor: 11.205

9. Poliovirus metabolism and the cytoskeletal framework: detergent extraction and resinless section electron microscopy.

Authors: H G Weed; G Krochmalnic; S Penman
Journal: J Virol Date: 1985-11 Impact factor: 5.103

10. Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: evidence for membrane cycling from Golgi to ER.

Authors: J Lippincott-Schwartz; L C Yuan; J S Bonifacino; R D Klausner
Journal: Cell Date: 1989-03-10 Impact factor: 41.582

117 in total

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Authors: C A Blank; D A Anderson; M Beard; S M Lemon
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2. Complex dynamic development of poliovirus membranous replication complexes.

Authors: George A Belov; Vinod Nair; Bryan T Hansen; Forrest H Hoyt; Elizabeth R Fischer; Ellie Ehrenfeld
Journal: J Virol Date: 2011-11-09 Impact factor: 5.103

3. Viral infection: Moving through complex and dynamic cell-membrane structures.

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Review 4. Expanding knowledge of P3 proteins in the poliovirus lifecycle.

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Journal: Future Microbiol Date: 2010-06 Impact factor: 3.165

Review 5. A guide to viral inclusions, membrane rearrangements, factories, and viroplasm produced during virus replication.

Authors: Christopher Netherton; Katy Moffat; Elizabeth Brooks; Thomas Wileman
Journal: Adv Virus Res Date: 2007 Impact factor: 9.937

6. Grapevine fanleaf virus replication occurs on endoplasmic reticulum-derived membranes.

Authors: C Ritzenthaler; C Laporte; F Gaire; P Dunoyer; C Schmitt; S Duval; A Piéquet; A M Loudes; O Rohfritsch; C Stussi-Garaud; P Pfeiffer
Journal: J Virol Date: 2002-09 Impact factor: 5.103

7. Isolation of enzymatically active replication complexes from feline calicivirus-infected cells.

Authors: Kim Y Green; Aaron Mory; Mark H Fogg; Andrea Weisberg; Gaël Belliot; Mariam Wagner; Tanaji Mitra; Ellie Ehrenfeld; Craig E Cameron; Stanislav V Sosnovtsev
Journal: J Virol Date: 2002-09 Impact factor: 5.103

8. Picornavirus genome replication. Identification of the surface of the poliovirus (PV) 3C dimer that interacts with PV 3Dpol during VPg uridylylation and construction of a structural model for the PV 3C2-3Dpol complex.

Authors: Miaoqing Shen; Zachary J Reitman; Yan Zhao; Ibrahim Moustafa; Qixin Wang; Jamie J Arnold; Harsh B Pathak; Craig E Cameron
Journal: J Biol Chem Date: 2007-11-09 Impact factor: 5.157

9. Poliovirus protein 3AB forms a complex with and stimulates the activity of the viral RNA polymerase, 3Dpol.

Authors: S J Plotch; O Palant
Journal: J Virol Date: 1995-11 Impact factor: 5.103

10. Assembly and maturation of the flavivirus Kunjin virus appear to occur in the rough endoplasmic reticulum and along the secretory pathway, respectively.

Authors: J M Mackenzie; E G Westaway
Journal: J Virol Date: 2001-11 Impact factor: 5.103