| Literature DB >> 1312314 |
Y L Abouya1, A Beaumel, S Lucas, A Dago-Akribi, G Coulibaly, M N'Dhatz, J B Konan, A Yapi, K M De Cock.
Abstract
Admissions and deaths in a pulmonary medicine ward in Abidjan, Cote d'Ivoire, West Africa, were evaluated over a 6-month period in 1989 with systematic autopsies on all patients who died. Of 473 patients admitted, 38% were HIV-1 seropositive, 4% were HIV-2 seropositive, and 14% reacted to both viruses. A total of 100 patients (21%) died, and deaths were twice as frequent in HIV-seropositive compared with HIV-negative patients. The pathology of 78 autopsies showed that the predominant cause of death in HIV-seropositive patients was disseminated tuberculosis (40%). Cancer was the cause of death in 64% of HIV-negative patients. Pneumocystosis was found in only 9% of HIV-seropositive autopsies. Since Pneumocystis carinii is an uncommon cause of death in this population, prophylaxis for P. carinii pneumonia is not warranted for HIV-infected patients in Africa. In contrast, research on chemoprophylaxis for tuberculosis is urgently required.Entities:
Keywords: Acquired Immunodeficiency Syndrome; Africa; Africa South Of The Sahara; Biology; Cancer; Causes Of Death; Clinical Research; Comparative Studies; Demographic Factors; Developing Countries; Diseases; Examinations And Diagnoses; French Speaking Africa; Histology; Hiv Infections; Infections; Ivory Coast; Laboratory Examinations And Diagnoses; Methodological Studies; Mortality; Neoplasms; Physiology; Population; Population Dynamics; Pulmonary Effects; Research Methodology; Respiratory Infections; Studies; Tuberculosis; Viral Diseases; Western Africa
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Year: 1992 PMID： 1312314 DOI： 10.1164/ajrccm/145.3.617
Source DB: PubMed Journal: Am Rev Respir Dis ISSN： 0003-0805