| Literature DB >> 1312305 |
P K Peterson1, C C Chao, S Hu, K Thielen, E G Shaskan.
Abstract
The development of Candida meningitis in a patient following partial resection of a glioblastoma raised suspicion that transforming growth factor (TGF-beta), an immunosuppressive cytokine known to be produced by this tumor, would be elevated in his cerebrospinal fluid (CSF). By using a highly specific bioassay, the concentration of TGF-beta was found to be 609 pg/mL, which was 10-fold greater than the mean CSF TGF-beta value in control subjects with no neurologic disease. Increased CSF TGF-beta levels were also detected in patients with other central nervous system (CNS) diseases: malignancies and AIDS dementia complex. These findings suggest that TGF-beta may play an immunopathogenetic role in the CNS.Entities:
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Year: 1992 PMID： 1312305 DOI： 10.1016/0002-9343(92)90075-m
Source DB: PubMed Journal: Am J Med ISSN： 0002-9343 Impact factor: 4.965