Literature DB >> 1312041

Endothelin stimulates both cAMP formation and phosphatidylinositol hydrolysis in cultured embryonic bovine tracheal cells.

K Oda1, Y Fujitani, T Watakabe, T Inui, T Okada, Y Urade, E Okuda-Ashitaka, S Ito.   

Abstract

Embryonic bovine tracheal (EBTr) cells were found to possess receptors for endothelin (ET) of ET-1-selective (ETA) subtype with a Kd for ET-1 of 114 pM and a Bmax of 12.9 fmol/10(5) cells. Stimulation of EBTr cells with 100 pM to 100 nM ET-1 increased the contents of both inositol phosphates and cAMP in a concentration-dependent manner, indicating that the receptors are coupled to both phosphatidylinositol hydrolysis and cAMP formation in EBTr cells.

Entities:  

Mesh：

Substances：

Year:  1992        PMID： 1312041     DOI： 10.1016/0014-5793(92)80244-b

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  9 in total

Review 1.  Endothelin receptor heterogeneity, G-proteins, and signaling via cAMP and cGMP cascades.

Authors:  M Sokolovsky
Journal:  Cell Mol Neurobiol       Date:  1995-10       Impact factor: 5.046

2.  Endothelins-induce cyclicAMP formation in the guinea-pig trachea through an ETA receptor- and cyclooxygenase-dependent mechanism.

Authors:  A M el-Mowafy; G A Abou-Mohamed
Journal:  Br J Pharmacol       Date:  1996-06       Impact factor: 8.739

3.  Effects of several endothelin receptor antagonists on gastrointestinal transit of guinea pigs.

Authors:  K Kuwahara; Y Kitsukawa; Y Suzuki; Y Saito
Journal:  Dig Dis Sci       Date:  2000-05       Impact factor: 3.199

4.  Expression of Ca(2+)-mobilizing endothelin(A) receptors and their role in the control of Ca(2+) influx and growth hormone secretion in pituitary somatotrophs.

Authors:  M Tomić; D Zivadinovic; F Van Goor; D Yuan; T Koshimizu; S S Stojilkovic
Journal:  J Neurosci       Date:  1999-09-15       Impact factor: 6.167

5.  Regional modulation of cyclic nucleotides by endothelin-1 in rat pulmonary arteries: direct activation of G(i)2-protein in the main pulmonary artery.

Authors:  I Mullaney; D M Vaughan; M R MacLean
Journal:  Br J Pharmacol       Date:  2000-03       Impact factor: 8.739

6.  Inhibition of basal and stimulated release of endothelin-1 from guinea pig tracheal epithelial cells in culture by beta 2-adrenoceptor agonists and cyclic AMP enhancers.

Authors:  Quan Yang; Bruno Battistini; Stéphane Pelletier; Pierre Sirois
Journal:  Inflammation       Date:  2007-10       Impact factor: 4.092

7.  Endothelin potentiates TRPV1 via ETA receptor-mediated activation of protein kinase C.

Authors:  Tim D Plant; Christian Zöllner; Frauke Kepura; Shaaban S Mousa; Jenny Eichhorst; Michael Schaefer; Jens Furkert; Christoph Stein; Alexander Oksche
Journal:  Mol Pain       Date:  2007-11-14       Impact factor: 3.395

8.  Endothelin-1/endothelin A receptor-mediated biased signaling is a new player in modulating human ovarian cancer cell tumorigenesis.

Authors:  Jian-peng Teoh; Kyoung-mi Park; Yongchao Wang; Qiuping Hu; Sangmi Kim; Guangyu Wu; Shuang Huang; Nita Maihle; Il-man Kim
Journal:  Cell Signal       Date:  2014-09-03       Impact factor: 4.315

9.  A maxi Cl- channel coupled to endothelin B receptors in the basolateral membrane of guinea-pig parietal cells.

Authors:  H Kajita; T Kotera; Y Shirakata; S Ueda; M Okuma; K Oda-Ohmae; M Takimoto; Y Urade; Y Okada
Journal:  J Physiol       Date:  1995-10-01       Impact factor: 5.182
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.