Literature DB >> 1311954

Mammalian protein serine/threonine phosphatase 2C: cDNA cloning and comparative analysis of amino acid sequences.

D J Mann1, D G Campbell, C H McGowan, P T Cohen.   

Abstract

Complementary DNA encoding rat protein phosphatase 2C alpha was obtained from a liver library and used to isolate the homologous cDNAs from rabbit liver and human teratocarcinoma libraries. The amino acid sequences of the three enzymes deduced from the cDNA (382 amino acids) were extremely similar (greater than 99% identity), the maximum number of differences (between rat and human) being four. Amino acid sequences of peptides corresponding to 238 residues (61%) of the protein phosphatase 2C beta isoform from rabbit skeletal muscle were determined and showed 12 differences from the recently published sequence of the rat liver enzyme deduced from the cDNA (95% identity).

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Year:  1992        PMID: 1311954     DOI: 10.1016/0167-4781(92)90471-b

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN: 0006-3002


  21 in total

Review 1.  The role of serine/threonine protein phosphatases in exocytosis.

Authors:  Alistair T R Sim; Monique L Baldwin; John A P Rostas; Jeff Holst; Russell I Ludowyke
Journal:  Biochem J       Date:  2003-08-01       Impact factor: 3.857

2.  Evolution of the metazoan protein phosphatase 2C superfamily.

Authors:  Adi Stern; Eyal Privman; Michal Rasis; Sara Lavi; Tal Pupko
Journal:  J Mol Evol       Date:  2006-12-06       Impact factor: 2.395

3.  Molecular cloning in Arabidopsis thaliana of a new protein phosphatase 2C (PP2C) with homology to ABI1 and ABI2.

Authors:  P L Rodriguez; M P Leube; E Grill
Journal:  Plant Mol Biol       Date:  1998-11       Impact factor: 4.076

4.  The type 2C Ser/Thr phosphatase PP2Cgamma is a pre-mRNA splicing factor.

Authors:  M V Murray; R Kobayashi; A R Krainer
Journal:  Genes Dev       Date:  1999-01-01       Impact factor: 11.361

5.  Enzymatic and functional analysis of a protein phosphatase, Pph3, from Myxococcus xanthus.

Authors:  Yoshio Kimura; Yumi Mori; Youhei Ina; Kaoru Takegawa
Journal:  J Bacteriol       Date:  2011-03-11       Impact factor: 3.490

6.  MP2C, a plant protein phosphatase 2C, functions as a negative regulator of mitogen-activated protein kinase pathways in yeast and plants.

Authors:  I Meskiene; L Bögre; W Glaser; J Balog; M Brandstötter; K Zwerger; G Ammerer; H Hirt
Journal:  Proc Natl Acad Sci U S A       Date:  1998-02-17       Impact factor: 11.205

7.  The protein phosphatases of Synechocystis sp. strain PCC 6803: open reading frames sll1033 and sll1387 encode enzymes that exhibit both protein-serine and protein-tyrosine phosphatase activity in vitro.

Authors:  Renhui Li; M Ben Potters; Liang Shi; Peter J Kennelly
Journal:  J Bacteriol       Date:  2005-09       Impact factor: 3.490

8.  Protein phosphatase 2Calpha inhibits the human stress-responsive p38 and JNK MAPK pathways.

Authors:  M Takekawa; T Maeda; H Saito
Journal:  EMBO J       Date:  1998-08-17       Impact factor: 11.598

9.  TPD1 of Saccharomyces cerevisiae encodes a protein phosphatase 2C-like activity implicated in tRNA splicing and cell separation.

Authors:  M K Robinson; W H van Zyl; E M Phizicky; J R Broach
Journal:  Mol Cell Biol       Date:  1994-06       Impact factor: 4.272

10.  Protein phosphatase 2C, encoded by ptc1+, is important in the heat shock response of Schizosaccharomyces pombe.

Authors:  K Shiozaki; H Akhavan-Niaki; C H McGowan; P Russell
Journal:  Mol Cell Biol       Date:  1994-06       Impact factor: 4.272

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