Literature DB >> 1311487

Protective efficacy of virus-like particles for bluetongue disease.

P Roy1, T French, B J Erasmus.   

Abstract

Bluetongue virus-like particles (VLPs) derived from multiple baculovirus expression vectors have been administered in the presence of various adjuvants to sheep, a vertebrate host susceptible to the virus, and the neutralizing antibody responses are measured. Vaccinated sheep are challenged after 4 months of inoculation, and clinical reaction indices and viraemia determined. The results indicate that these multiprotein virus-like particles lacking the genetic material are highly immunogenic and as little as 10 micrograms of VLPs in conjunction with appropriate adjuvant elicit an immune response which protects against infectious virus challenge. The formation of virus-like particles using this new technology offers a novel approach in vaccinology.

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Year:  1992        PMID： 1311487     DOI： 10.1016/0264-410x(92)90415-g

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  25 in total

Review 1.  Prospects for improved bluetongue vaccines.

Authors:  Polly Roy; Mark Boyce; Robert Noad
Journal:  Nat Rev Microbiol       Date:  2009-02       Impact factor: 60.633

Review 2.  Producing recombinant adeno-associated virus in foster cells: overcoming production limitations using a baculovirus-insect cell expression strategy.

Authors:  Tamas Virag; Sylvain Cecchini; Robert M Kotin
Journal:  Hum Gene Ther       Date:  2009-08       Impact factor: 5.695

3.  In vitro reconstitution of Bluetongue virus infectious cores.

Authors:  Sofia Lourenco; Polly Roy
Journal:  Proc Natl Acad Sci U S A       Date:  2011-08-01       Impact factor: 11.205

4.  Expression of human papillomavirus type 11 L1 protein in insect cells: in vivo and in vitro assembly of viruslike particles.

Authors:  R C Rose; W Bonnez; R C Reichman; R L Garcea
Journal:  J Virol       Date:  1993-04       Impact factor: 5.103

5.  Development of baculovirus triple and quadruple expression vectors: co-expression of three or four bluetongue virus proteins and the synthesis of bluetongue virus-like particles in insect cells.

Authors:  A S Belyaev; P Roy
Journal:  Nucleic Acids Res       Date:  1993-03-11       Impact factor: 16.971

6.  An updated review on bluetongue virus: epidemiology, pathobiology, and advances in diagnosis and control with special reference to India.

Authors:  Mani Saminathan; Karam Pal Singh; Jaynudin Hajibhai Khorajiya; Murali Dinesh; Sobharani Vineetha; Madhulina Maity; At Faslu Rahman; Jyoti Misri; Yashpal Singh Malik; Vivek Kumar Gupta; Raj Kumar Singh; Kuldeep Dhama
Journal:  Vet Q       Date:  2020-12       Impact factor: 3.320

7.  Generation of replication-defective virus-based vaccines that confer full protection in sheep against virulent bluetongue virus challenge.

Authors:  Eiko Matsuo; Cristina C P Celma; Mark Boyce; Cyril Viarouge; Corinne Sailleau; Eric Dubois; Emmanuel Bréard; Richard Thiéry; Stéphan Zientara; Polly Roy
Journal:  J Virol       Date:  2011-07-27       Impact factor: 5.103

8.  Oncolytic bluetongue viruses: promise, progress, and perspectives.

Authors:  Joseph K-K Li
Journal:  Front Microbiol       Date:  2011-03-16       Impact factor: 5.640

9.  Multigene expression of protein complexes by iterative modification of genomic Bacmid DNA.

Authors:  Rob J Noad; Meredith Stewart; Mark Boyce; Cristina C Celma; Keith R Willison; Polly Roy
Journal:  BMC Mol Biol       Date:  2009-09-02       Impact factor: 2.946

10.  Canine parvovirus VP2 protein expressed in silkworm pupae self-assembles into virus-like particles with high immunogenicity.

Authors:  Hao Feng; Gui-qiu Hu; Hua-lei Wang; Meng Liang; Hongru Liang; He Guo; Pingsen Zhao; Yu-jiao Yang; Xue-xing Zheng; Zhi-fang Zhang; Yong-kun Zhao; Yu-wei Gao; Song-tao Yang; Xian-zhu Xia
Journal:  PLoS One       Date:  2014-01-17       Impact factor: 3.240
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