Literature DB >> 1311374

Immunohistochemical demonstration of the Epstein-Barr virus-encoded latent membrane protein in paraffin sections of Hodgkin's disease.

P G Murray1, L S Young, M Rowe, J Crocker.   

Abstract

Paraffin sections from 46 cases of Hodgkin's disease were examined for the presence of the Epstein-Barr virus (EBV)-encoded latent membrane protein (LMP) using a sensitive (double layer alkaline phosphatase-anti-alkaline phosphatase) immunohistochemical method. LMP was detected in 22 cases, the majority of positive cases being of nodular sclerosis (12/24), mixed cellularity (6/7), and lymphocyte depletion (3/3) subtypes. Only one of 12 cases of lymphocyte predominant disease was positive. In all cases, reactivity was confined to Hodgkin's and Reed-Sternberg cells. These results provide further evidence for an association between EBV and Hodgkin's disease and indicate that LMP may be readily detected in archival material.

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Year:  1992        PMID： 1311374     DOI： 10.1002/path.1711660102

Source DB:  PubMed          Journal:  J Pathol        ISSN： 0022-3417            Impact factor:   7.996


  35 in total

1.  Detection of Epstein-Barr virus in archival Hodgkin's disease specimens.

Authors:  K J Flavell; J A Linford; J R Flavell; P G Murray; L S Young; K Scott
Journal:  Mol Pathol       Date:  2000-06

Review 2.  Human herpesvirus 6.

Authors:  D K Braun; G Dominguez; P E Pellett
Journal:  Clin Microbiol Rev       Date:  1997-07       Impact factor: 26.132

Review 3.  Hodgkin's disease and the Epstein-Barr virus.

Authors:  K J Flavell; P G Murray
Journal:  Mol Pathol       Date:  2000-10

4.  Epstein-Barr virus and Hodgkin's lymphoma in Cairo, Egypt.

Authors:  Josée Audouin; Jacques Diebold; Bharat Nathwani; Elia Ishak; Kenneth Maclennan; Hans Konrad Mueller-Hermelink; James O Armitage; Dennis D Weisenburger
Journal:  J Hematop       Date:  2010-05-28       Impact factor: 0.196

5.  Lymphocyte-predominant Hodgkin's disease. An immunohistochemical analysis of 208 reviewed Hodgkin's disease cases from the German Hodgkin Study Group.

Authors:  R von Wasielewski; M Werner; R Fischer; M L Hansmann; K Hübner; D Hasenclever; J Franklin; M Sextro; V Diehl; A Georgii
Journal:  Am J Pathol       Date:  1997-03       Impact factor: 4.307

6.  Increased expression of CD4+CD25 +FOXP3+ regulatory T cells correlates with Epstein-Barr virus and has no impact on survival in patients with classical Hodgkin lymphoma in Brazil.

Authors:  Mariane C G Assis; Antonio H F M Campos; Jose S R Oliveira; Fernando A Soares; Joyce M K Silva; Priscilla B Silva; Adriana D Penna; Eni M Souza; Otavio C G Baiocchi
Journal:  Med Oncol       Date:  2012-07-13       Impact factor: 3.064

Review 7.  The Epstein-Barr virus and its association with human cancers.

Authors:  K R Baumforth; L S Young; K J Flavell; C Constandinou; P G Murray
Journal:  Mol Pathol       Date:  1999-12

8.  Matrix metalloproteinase-9 is consistently expressed in Hodgkin/Reed-Sternberg cells and has no impact on survival in patients with Epstein-Barr virus (EBV)-related and non-related Hodgkin lymphoma in Brazil.

Authors:  Eni M Souza; Otávio C G Baiocchi; Maria A Zanichelli; Antonio C Alves; Marianne G Assis; Joyce M K Silva; Cristine Dobo; José S R Oliveira
Journal:  Med Oncol       Date:  2011-09-16       Impact factor: 3.064

9.  EBV may be expressed in the LP cells of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) in both children and adults.

Authors:  Alison R Huppmann; Alina Nicolae; Graham W Slack; Stefania Pittaluga; Theresa Davies-Hill; Judith A Ferry; Nancy Lee Harris; Elaine S Jaffe; Robert P Hasserjian
Journal:  Am J Surg Pathol       Date:  2014-03       Impact factor: 6.394

10.  Deletion of DNA encoding the first five transmembrane domains of Epstein-Barr virus latent membrane proteins 2A and 2B.

Authors:  R Longnecker; C L Miller; B Tomkinson; X Q Miao; E Kieff
Journal:  J Virol       Date:  1993-08       Impact factor: 5.103
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