Literature DB >> 1311198

Okadaic acid--a valuable new tool for the study of signal transduction and cell cycle regulation?

A Schönthal1.   

Abstract

Okadaic acid is beginning to find its way into laboratories that study cellular control of gene expression and proliferation. By virtue of its specific inhibitory effects on certain protein phosphatases it seems to be a powerful tool for the analysis of regulatory phosphorylation-dephosphorylation events. Here, some of the important new findings with the use of this drug are summarized, and a few potential drawbacks of its application discussed.

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Year:  1992        PMID： 1311198

Source DB:  PubMed          Journal:  New Biol        ISSN： 1043-4674


  11 in total

1.  Interleukin-1beta expression after inhibition of protein phosphatases in endotoxin-tolerant cells.

Authors:  B K Yoza; J D Wells; C E McCall
Journal:  Clin Diagn Lab Immunol       Date:  1998-05

2.  Cell activation mediated by glycosylphosphatidylinositol-anchored or transmembrane forms of CD14.

Authors:  J Pugin; V V Kravchenko; J D Lee; L Kline; R J Ulevitch; P S Tobias
Journal:  Infect Immun       Date:  1998-03       Impact factor: 3.441

3.  The protein phosphatase inhibitor okadaic acid suppresses type I collagen gene expression in cultured fibroblasts at the transcriptional level.

Authors:  J Westermarck; E Ilvonen; V M Kähäri
Journal:  Biochem J       Date:  1995-06-15       Impact factor: 3.857

4.  Okadaic acid regulation of the retinoblastoma gene product is correlated with the inhibition of growth factor-induced cell proliferation in mouse fibroblasts.

Authors:  T A Kim; B R Velasquez; C E Wenner
Journal:  Proc Natl Acad Sci U S A       Date:  1993-06-15       Impact factor: 11.205

5.  Protein phosphatase 2A potentiates activity of promoters containing AP-1-binding elements.

Authors:  A S Alberts; T Deng; A Lin; J L Meinkoth; A Schönthal; M C Mumby; M Karin; J R Feramisco
Journal:  Mol Cell Biol       Date:  1993-04       Impact factor: 4.272

6.  Comparison of the effects of insulin and okadaic acid on phosphoenolpyruvate carboxykinase gene expression.

Authors:  R M O'Brien; E L Noisin; D K Granner
Journal:  Biochem J       Date:  1994-11-01       Impact factor: 3.857

7.  Visualization of second polar body chromosomes in fertilized and artificially activated mouse oocytes treated with okadaic acid.

Authors:  A P Dyban; P De Sutter; D Dozortsev; Y Verlinsky
Journal:  J Assist Reprod Genet       Date:  1992-12       Impact factor: 3.412

8.  Expression of a peptide inhibitor of protein phosphatase 1 increases phosphorylation and activity of CREB in NIH 3T3 fibroblasts.

Authors:  A S Alberts; M Montminy; S Shenolikar; J R Feramisco
Journal:  Mol Cell Biol       Date:  1994-07       Impact factor: 4.272

9.  Transient activation of RAF-1, MEK, and ERK2 coincides kinetically with ternary complex factor phosphorylation and immediate-early gene promoter activity in vivo.

Authors:  R A Hipskind; M Baccarini; A Nordheim
Journal:  Mol Cell Biol       Date:  1994-09       Impact factor: 4.272

10.  Okadaic acid, an inhibitor of protein phosphatase 1 and 2A, induces premature separation of sister chromatids during meiosis I and aneuploidy in mouse oocytes in vitro.

Authors:  John B Mailhes; Colette Hilliard; John W Fuseler; Steve N London
Journal:  Chromosome Res       Date:  2003       Impact factor: 4.620
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