Literature DB >> 13109099

Susceptibility of mice free of Theiler's virus (TO strain) to infection with TO virus.

E T FELTZ, B MANDEL, E RACKER.   

Abstract

A method for the establishment and maintenance of a colony of mice free of Theiler's (TO) virus has been described. This colony has been maintained since 1947 with but one instance of contamination in 1948. Studies on the susceptibility of these mice to TO virus show that smaller doses are required to establish an infection of the intestinal tract than of the CNS. A mutant strain of TO(B) virus has been isolated which, following oral administration to mice free of TO virus, is able to cause infection of the CNS with paralysis. When fed to stock mice that carry TO virus, this TO(B) strain does not cause paralysis or other signs of CNS infection.

Entities:  

Keywords:  ENCEPHALOMYELITIS/experimental; VIRUSES

Mesh：

Year:  1953        PMID： 13109099      PMCID： PMC2136333          DOI： 10.1084/jem.98.5.427

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  6 in total

1.  Individual Isolation of Infected Animals in a Single Room.

Authors:  F L Horsfall; J H Bauer
Journal:  J Bacteriol       Date:  1940-10       Impact factor: 3.490

2.  Breeding of a colony of white mice free of encephalomyelitis virus.

Authors:  H VON MAGNUS; P VON MAGNUS
Journal:  Acta Pathol Microbiol Scand       Date:  1949

3.  Studies on the relationship between the Theiler group of viruses and the intestinal tract of the mouse.

Authors:  B MANDEL
Journal:  Bull N Y Acad Med       Date:  1951-09

4.  Mouse encephalomyelitis; immunologic studies of a non-infected colony.

Authors:  D J DEAN
Journal:  J Immunol       Date:  1951-03       Impact factor: 5.422

5.  Studies on mouse encephalomyelitis virus (TO strain). II. The susceptibility of ordinary albino mice compared with that of a colony of TO-free mice to TO virus inoculated by various routes.

Authors:  H von MAGNUS
Journal:  Acta Pathol Microbiol Scand       Date:  1950

6.  SPONTANEOUS ENCEPHALOMYELITIS OF MICE, A NEW VIRUS DISEASE.

Authors:  M Theiler
Journal:  J Exp Med       Date:  1937-04-30       Impact factor: 14.307
  6 in total
  2 in total

1.  A single base deletion in the 5' noncoding region of Theiler's virus attenuates neurovirulence.

Authors:  A E Pritchard; M A Calenoff; S Simpson; K Jensen; H L Lipton
Journal:  J Virol       Date:  1992-04       Impact factor: 5.103

2.  Phylogenetic analysis of the species Theilovirus: emerging murine and human pathogens.

Authors:  Zhiguo Liang; A S Manoj Kumar; Morris S Jones; Nick J Knowles; Howard L Lipton
Journal:  J Virol       Date:  2008-09-24       Impact factor: 5.103
  2 in total

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