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Literature DB >> 1310857

Sequence alignment of the G-protein coupled receptor superfamily.

W C Probst¹, L A Snyder, D I Schuster, J Brosius, S C Sealfon.

Abstract

The multitude of G-protein coupled receptor (GPR) superfamily cDNAs recently isolated has exceeded the number of receptor subtypes anticipated by pharmacological studies. Analysis of the sequence similarities and unique features of the members of this family is valuable for designing strategies to isolate related cDNAs, for developing hypotheses concerning substrate-ligand and receptor-effector interactions, and for understanding the evolution of these genes. We have compiled and aligned the 74 unique amino acid sequences published to date and review the present understanding of the structural motifs contributing to ligand binding and G-protein coupling.

Entities: Gene

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Year: 1992 PMID： 1310857 DOI： 10.1089/dna.1992.11.1

Source DB: PubMed Journal: DNA Cell Biol ISSN： 1044-5498 Impact factor: 3.311

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Cited

124 in total

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Journal: J Comput Aided Mol Des Date: 1999-07 Impact factor: 3.686

2. 5-Hydroxytryptamine 4(a) receptor expressed in Sf9 cells is palmitoylated in an agonist-dependent manner.

Authors: E G Ponimaskin; M F Schmidt; M Heine; U Bickmeyer; D W Richter
Journal: Biochem J Date: 2001-02-01 Impact factor: 3.857

3. The variable and conserved interfaces of modeled olfactory receptor proteins.

Authors: Y Pilpel; D Lancet
Journal: Protein Sci Date: 1999-05 Impact factor: 6.725

4. Substitution of a mutant alpha2a-adrenergic receptor via "hit and run" gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo.

Authors: P P Lakhlani; L B MacMillan; T Z Guo; B A McCool; D M Lovinger; M Maze; L E Limbird
Journal: Proc Natl Acad Sci U S A Date: 1997-09-02 Impact factor: 11.205

Sequence alignment of the G-protein coupled receptor superfamily.

1. Molecular modeling study of the differential ligand-receptor interaction at the mu, delta and kappa opioid receptors.

2. 5-Hydroxytryptamine 4(a) receptor expressed in Sf9 cells is palmitoylated in an agonist-dependent manner.

3. The variable and conserved interfaces of modeled olfactory receptor proteins.

4. Substitution of a mutant alpha2a-adrenergic receptor via "hit and run" gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo.

5. Structural insight into the role of the human melanocortin 3 receptor cysteine residues on receptor function.

6. Degenerate suppression PCR identifies the beta2-adrenergic receptor as upregulated by neuronal differentiation.

7. Brain and gastrointestinal cholecystokinin receptor family: structure and functional expression.

Review 8. Ion channels and signaling in the pituitary gland.

9. Pain imaging in the emerging era of molecular medicine.

Review 10. Pharmacology of signaling induced by dopamine D(1)-like receptor activation.