OBJECTIVE: We sought to determine the antiinflammatory properties of lymecycline in the long-term treatment of reactive arthritis (ReA). METHODS: Quantitative assay of collagenase activity by densitometry after sodium dodecyl sulfate-polyacrylamide gel electrophoresis. RESULTS: Therapeutic levels of lymecycline do not directly inhibit the activity of human neutrophil interstitial collagenase, but can prevent the oxidative activation of latent human neutrophil collagenase. CONCLUSION: This non-antimicrobial, anticollagenolytic property of lymecycline may contribute to its therapeutic efficacy in the treatment of patients with ReA.
OBJECTIVE: We sought to determine the antiinflammatory properties of lymecycline in the long-term treatment of reactive arthritis (ReA). METHODS: Quantitative assay of collagenase activity by densitometry after sodium dodecyl sulfate-polyacrylamide gel electrophoresis. RESULTS: Therapeutic levels of lymecycline do not directly inhibit the activity of human neutrophil interstitial collagenase, but can prevent the oxidative activation of latent humanneutrophil collagenase. CONCLUSION: This non-antimicrobial, anticollagenolytic property of lymecycline may contribute to its therapeutic efficacy in the treatment of patients with ReA.
Authors: T Yli-Kerttula; R Luukkainen; U Yli-Kerttula; T Möttönen; M Hakola; M Korpela; M Sanila; J Parviainen; J Uksila; R Vainionpää; A Toivanen Journal: Ann Rheum Dis Date: 2000-07 Impact factor: 19.103
Authors: D Nordstrom; O Lindy; Y T Konttinen; A Lauhio; T Sorsa; C Friman; T Pettersson; S Santavirta Journal: Clin Rheumatol Date: 1996-01 Impact factor: 2.980
Authors: A Lauhio; Y T Konttinen; H Tschesche; D Nordström; T Salo; J Lähdevirta; L M Golub; T Sorsa Journal: Antimicrob Agents Chemother Date: 1994-02 Impact factor: 5.191
Authors: A Lauhio; T Salo; Y Ding; Y T Konttinen; D Nordström; H Tschesche; J Lähdevirta; L M Golub; T Sorsa Journal: Clin Exp Immunol Date: 1994-10 Impact factor: 4.330
Authors: T Sorsa; T Ingman; K Suomalainen; M Haapasalo; Y T Konttinen; O Lindy; H Saari; V J Uitto Journal: Infect Immun Date: 1992-11 Impact factor: 3.441
Authors: T Sorsa; O Lindy; Y T Konttinen; K Suomalainen; T Ingman; H Saari; S Halinen; H M Lee; L M Golub; J Hall Journal: Antimicrob Agents Chemother Date: 1993-03 Impact factor: 5.191