Literature DB >> 1310068

Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer.

Y Miki1, I Nishisho, A Horii, Y Miyoshi, J Utsunomiya, K W Kinzler, B Vogelstein, Y Nakamura.   

Abstract

The APC gene is responsible for familial adenomatous polyposis and is considered to be a tumor suppressor gene associated with development of sporadic colorectal tumors. Here we report the disruption of the APC gene caused by somatic insertion of a long interspersed repetitive element (LINE-1 sequence) into the last exon of the APC gene in a colon cancer. The inserted sequence was composed of a 3' portion of the LINE-1 consensus sequence and nearly 180 base pairs of polyadenylate tract. Furthermore, since an 8-base pair target site duplication was observed, retrotranscriptional insertion of an active LINE-1 sequence is suspected as the cause of this insertion event. This is the first report of the disruption of a tumor suppressor gene caused by somatic insertion of a mobile genetic element.

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Year:  1992        PMID： 1310068

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  235 in total

Review 1.  Active human retrotransposons: variation and disease.

Authors:  Dustin C Hancks; Haig H Kazazian
Journal:  Curr Opin Genet Dev       Date:  2012-03-08       Impact factor: 5.578

2.  "Rogue" lymphocytes among Ukrainians not exposed to radioactive fall-out from the Chernobyl accident: the possible role of this phenomenon in oncogenesis, teratogenesis, and mutagenesis.

Authors:  J V Neel; A A Awa; Y Kodama; M Nakano; K Mabuchi
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-01       Impact factor: 11.205

3.  Phosphorylation of ORF1p is required for L1 retrotransposition.

Authors:  Pamela R Cook; Charles E Jones; Anthony V Furano
Journal:  Proc Natl Acad Sci U S A       Date:  2015-03-23       Impact factor: 11.205

4.  Intact piRNA pathway prevents L1 mobilization in male meiosis.

Authors:  Simon J Newkirk; Suman Lee; Fiorella C Grandi; Valeriya Gaysinskaya; James M Rosser; Nicole Vanden Berg; Cathryn A Hogarth; Maria C N Marchetto; Alysson R Muotri; Michael D Griswold; Ping Ye; Alex Bortvin; Fred H Gage; Jef D Boeke; Wenfeng An
Journal:  Proc Natl Acad Sci U S A       Date:  2017-06-19       Impact factor: 11.205

5.  L1 integration in a transgenic mouse model.

Authors:  Daria V Babushok; Eric M Ostertag; Christine E Courtney; Janice M Choi; Haig H Kazazian
Journal:  Genome Res       Date:  2005-12-19       Impact factor: 9.043

6.  Cell divisions are required for L1 retrotransposition.

Authors:  Xi Shi; Andrei Seluanov; Vera Gorbunova
Journal:  Mol Cell Biol       Date:  2006-12-04       Impact factor: 4.272

7.  Playing in the mud-using gene expression to assess contaminant effects on sediment dwelling invertebrates.

Authors:  Edward J Perkins; Guilherme R Lotufo
Journal:  Ecotoxicology       Date:  2003-12       Impact factor: 2.823

8.  Aberrant pre-mRNA maturation is caused by LINE insertions into introns of the white gene of Drosophila melanogaster.

Authors:  O Lajoinie; M E Drake; B Dastugue; C Vaury
Journal:  Nucleic Acids Res       Date:  1995-10-25       Impact factor: 16.971

9.  RNA polymerase III dependence of the human L1 promoter and possible participation of the RNA polymerase II factor YY1 in the RNA polymerase III transcription system.

Authors:  K Kurose; K Hata; M Hattori; Y Sakaki
Journal:  Nucleic Acids Res       Date:  1995-09-25       Impact factor: 16.971

10.  Meeting Report: The Role of the Mobilome in Cancer.

Authors:  Daniel Ardeljan; Martin S Taylor; Kathleen H Burns; Jef D Boeke; Michael Graham Espey; Elisa C Woodhouse; Thomas Kevin Howcroft
Journal:  Cancer Res       Date:  2016-07-18       Impact factor: 12.701
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