Literature DB >> 1309897

Finite life span of hybrids formed by fusion of different simian virus 40-immortalized human cell lines.

N J Whitaker1, E L Kidston, R R Reddel.   

Abstract

Simian virus 40 (SV40) genes are able to induce immortalization of normal human cells after a culture crisis during which unknown cellular genetic changes presumably occur. To determine whether these genetic changes are always identical, we performed somatic cell hybridization analysis of an SV40-immortalized human bronchial epithelial cell line, BET-1A. Fusion of BET-1A with an SV40-immortalized fibroblast cell line resulted in hybrids that senesced, indicating that these cell lines are in different complementation groups for immortalization.

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Year:  1992        PMID： 1309897      PMCID： PMC240827     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  12 in total

Review 1.  In vitro transformation of human epithelial cells.

Authors:  S E Chang
Journal:  Biochim Biophys Acta       Date:  1986

2.  Neoplastic transformation of human epidermal keratinocytes by AD12-SV40 and Kirsten sarcoma viruses.

Authors:  J S Rhim; G Jay; P Arnstein; F M Price; K K Sanford; S A Aaronson
Journal:  Science       Date:  1985-03-08       Impact factor: 47.728

3.  Transformation of human bronchial epithelial cells by infection with SV40 or adenovirus-12 SV40 hybrid virus, or transfection via strontium phosphate coprecipitation with a plasmid containing SV40 early region genes.

Authors:  R R Reddel; Y Ke; B I Gerwin; M G McMenamin; J F Lechner; R T Su; D E Brash; J B Park; J S Rhim; C C Harris
Journal:  Cancer Res       Date:  1988-04-01       Impact factor: 12.701

4.  Genetic analysis of indefinite division in human cells: identification of four complementation groups.

Authors:  O M Pereira-Smith; J R Smith
Journal:  Proc Natl Acad Sci U S A       Date:  1988-08       Impact factor: 11.205

5.  Human bronchial epithelial cells neoplastically transformed by v-Ki-ras: altered response to inducers of terminal squamous differentiation.

Authors:  R R Reddel; Y Ke; M E Kaighn; L Malan-Shibley; J F Lechner; J S Rhim; C C Harris
Journal:  Oncogene Res       Date:  1988

6.  Expression of SV40 T antigen in finite life-span hybrids of normal and SV40-transformed fibroblasts.

Authors:  O M Pereira-Smith; J R Smith
Journal:  Somatic Cell Genet       Date:  1981-07

7.  Replicative potentials of various fusion products between WI-38 and SV40 transformed WI-38 cells and their components.

Authors:  A L Muggleton-Harris; D W DeSimone
Journal:  Somatic Cell Genet       Date:  1980-11

8.  Induction of immortality is an early event in malignant transformation of mammalian cells by carcinogens.

Authors:  R F Newbold; R W Overell; J R Connell
Journal:  Nature       Date:  1982-10-14       Impact factor: 49.962

9.  Suppression of tumor growth by senescence in virally transformed human fibroblasts.

Authors:  W O'Brien; G Stenman; R Sager
Journal:  Proc Natl Acad Sci U S A       Date:  1986-11       Impact factor: 11.205

10.  Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene.

Authors:  R F Newbold; R W Overell
Journal:  Nature       Date:  1983 Aug 18-24       Impact factor: 49.962
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  5 in total

1.  Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes.

Authors:  M J Bertram; N G Bérubé; X Hang-Swanson; Q Ran; J K Leung; S Bryce; K Spurgers; R J Bick; A Baldini; Y Ning; L J Clark; E K Parkinson; J C Barrett; J R Smith; O M Pereira-Smith
Journal:  Mol Cell Biol       Date:  1999-02       Impact factor: 4.272

Review 2.  Human replicative senescence. A molecular study.

Authors:  P J Hensler; O M Pereira-Smith
Journal:  Am J Pathol       Date:  1995-07       Impact factor: 4.307

3.  Rat embryo fibroblasts immortalized with simian virus 40 large T antigen undergo senescence upon its inactivation.

Authors:  E S Gonos; J S Burns; G R Mazars; A Kobrna; T E Riley; S C Barnett; G Zafarana; R L Ludwig; Z Ikram; A J Powell; P S Jat
Journal:  Mol Cell Biol       Date:  1996-09       Impact factor: 4.272

4.  Telomere elongation in immortal human cells without detectable telomerase activity.

Authors:  T M Bryan; A Englezou; J Gupta; S Bacchetti; R R Reddel
Journal:  EMBO J       Date:  1995-09-01       Impact factor: 11.598

5.  Loss of wild-type ATRX expression in somatic cell hybrids segregates with activation of Alternative Lengthening of Telomeres.

Authors:  Kylie Bower; Christine E Napier; Sara L Cole; Rebecca A Dagg; Loretta M S Lau; Emma L Duncan; Elsa L Moy; Roger R Reddel
Journal:  PLoS One       Date:  2012-11-20       Impact factor: 3.240
  5 in total

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