The influenza virus: its morphology, immunology, and kinetics of multiplication.

The morphology of influenza virus is described, and the properties of its two components, the elementary body and the soluble substance, differentiated. The relationship between the filamentous and spherical structures observed in the infected allantoic fluid is still obscure, but the filaments are thought to represent either a form of influenza virus or a stage in its multiplication.The antigenic constitution of A and B viruses is discussed and variations in the pattern of individual strains over the past two decades described. The author outlines his speculations on the origin and mechanism of these variations. Other differences in serological behaviour, such as non-specific inhibition and the avidity effect, are discussed.The results of experimental investigation, with various animal hosts, of the kinetics of influenza virus multiplication are reviewed, and the effects of such factors as incubation temperature and concentration of the seed virus considered. The bearing of these studies of enzymatic virus/host-cell interactions on the chemotherapeutic control of influenza is emphasized.