Literature DB >> 1309277

A possible role for nonsense suppression in the synthesis of a human cytomegalovirus 58-kDa virion protein.

R S Lahijani1, E W Otteson, S C St Jeor.   

Abstract

A 1.6-kb late mRNA originating from the HindIII R fragment of human cytomegalovirus (HCMV) encodes a 58-kDa virion phosphoprotein. Data presented support the hypothesis that this protein may be synthesized via the translational readthrough of an opal termination codon separating two open reading frames located in tandem. To our knowledge this is the first report of nonsense suppression as a means of regulating gene expression in HCMV.

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Year:  1992        PMID： 1309277     DOI： 10.1016/0042-6822(92)90087-6

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  8 in total

Review 1.  Misreading of termination codons in eukaryotes by natural nonsense suppressor tRNAs.

Authors:  H Beier; M Grimm
Journal:  Nucleic Acids Res       Date:  2001-12-01       Impact factor: 16.971

2.  Proteins associated with purified human cytomegalovirus particles.

Authors:  C J Baldick; T Shenk
Journal:  J Virol       Date:  1996-09       Impact factor: 5.103

3.  Origin of biomolecular games: deception and molecular evolution.

Authors:  Steven E Massey; Bud Mishra
Journal:  J R Soc Interface       Date:  2018-09       Impact factor: 4.118

4.  The human cytomegalovirus UL35 gene encodes two proteins with different functions.

Authors:  Yingguang Liu; Bonita J Biegalke
Journal:  J Virol       Date:  2002-03       Impact factor: 5.103

5.  The human cytomegalovirus UL94 open reading frame encodes a conserved herpesvirus capsid/tegument-associated virion protein that is expressed with true late kinetics.

Authors:  B A Wing; G C Lee; E S Huang
Journal:  J Virol       Date:  1996-06       Impact factor: 5.103

6.  Analysis and mapping of a family of 3'-coterminal transcripts containing coding sequences for human cytomegalovirus open reading frames UL93 through UL99.

Authors:  B A Wing; E S Huang
Journal:  J Virol       Date:  1995-03       Impact factor: 5.103

7.  The human cytomegalovirus UL98 gene transcription unit overlaps with the pp28 true late gene (UL99) and encodes a 58-kilodalton early protein.

Authors:  B L Adam; T Y Jervey; C P Kohler; G L Wright; J A Nelson; R M Stenberg
Journal:  J Virol       Date:  1995-09       Impact factor: 5.103

8.  The human cytomegalovirus UL97 protein kinase, an antiviral drug target, is required at the stage of nuclear egress.

Authors:  Paula M Krosky; Moon-Chang Baek; Donald M Coen
Journal:  J Virol       Date:  2003-01       Impact factor: 5.103
  8 in total

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