Literature DB >> 1309203

Heterogeneity of radiosensitivity in a human glioma cell line.

X Yang1, J L Darling, T J McMillan, J H Peacock, G G Steel.   

Abstract

Sixteen clones were isolated from an early-passage human glioma cell line (IN859) and have been found to show variation in several biological characteristics including DNA content, modal chromosome number, and morphology. In addition, heterogeneity of radiosensitivity was detected: the doses that gave a surviving fraction of 0.01 varied by a factor of approximately 1.5. The most sensitive (clone 6) and the most resistant (clone 9) clones were selected for further study; their surviving fractions at 2Gy (SF2) were 0.37 and 0.64, respectively. When compared at a fixed radiation dose the sensitive clone surprisingly demonstrated greater split-dose recovery than the resistant clone; it also showed greater low dose-rate sparing.

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Year:  1992        PMID： 1309203     DOI： 10.1016/0360-3016(92)90988-t

Source DB:  PubMed          Journal:  Int J Radiat Oncol Biol Phys        ISSN： 0360-3016            Impact factor:   7.038


  7 in total

1.  Sensitivity of human glioma U-373MG cells to radiation and the protein kinase C inhibitor, calphostin C.

Authors:  M Acevedo-Duncan; J Pearlman; B Zachariah
Journal:  Cell Prolif       Date:  2001-02       Impact factor: 6.831

2.  Induction and characterization of human glioma clones with different radiosensitivities.

Authors:  J Wang; L Hu; N Gupta; T Shamseldin; T Ozawa; J Klem; M Cardell; D F Deen
Journal:  Neoplasia       Date:  1999-06       Impact factor: 5.715

3.  Effects of interferon and PKC modulators on human glioma protein kinase C, cell proliferation, and cell cycle.

Authors:  M Acevedo-Duncan; R Zhang; D R Cooper; H M Greenberg
Journal:  Neurochem Res       Date:  1997-07       Impact factor: 3.996

4.  Irradiation of the potential cancer stem cell niches in the adult brain improves progression-free survival of patients with malignant glioma.

Authors:  Patrick Evers; Percy P Lee; John DeMarco; Nzhde Agazaryan; James W Sayre; Michael Selch; Frank Pajonk
Journal:  BMC Cancer       Date:  2010-07-21       Impact factor: 4.430

5.  Gangliosides protect human melanoma cells from ionizing radiation-induced clonogenic cell death.

Authors:  C P Thomas; A Buronfosse; V Combaret; S Pedron; B Fertil; J Portoukalian
Journal:  Glycoconj J       Date:  1996-06       Impact factor: 2.916

6.  The gangliosides as a possible molecular coupling factor between the proportion of radiosensitive cells in vitro and the metastatic potential in vivo within a human melanoma cell line.

Authors:  C P Thomas; A Buronfosse; J Portoukalian; B Fertil
Journal:  Br J Cancer       Date:  1997       Impact factor: 7.640

7.  The Effect of X-Ray and Heavy Ions Radiations on Chemotherapy Refractory Tumor Cells.

Authors:  Zhan Yu; Carola Hartel; Diana Pignalosa; Wilma Kraft-Weyrather; Guo-Liang Jiang; David Diaz-Carballo; Marco Durante
Journal:  Front Oncol       Date:  2016-03-29       Impact factor: 6.244
  7 in total

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