Literature DB >> 1308474

Pharmacological properties and toxicology of MED-15, a prodrug of tolmetin.

A Caruso1, V M Cutuli, E De Bernardis, G Attaguile, M Amico-Roxas.   

Abstract

In this study the pharmacological evaluation of MED-15, a non-acidic prodrug of tolmetin, is described. After oral administration the new compound shows a marked anti-inflammatory activity similar to that of tolmetin, but with minor ulcerogenic action and lower acute toxicity.

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Year:  1992        PMID: 1308474

Source DB:  PubMed          Journal:  Drugs Exp Clin Res        ISSN: 0378-6501


  1 in total

1.  Gastrosparing effect of new antiinflammatory drug amtolmetin guacyl in the rat: involvement of nitric oxide.

Authors:  C Pisano; D Grandi; G Morini; G Coppelli; L Vesci; P Lo Giudice; S Pace; L Pacifici; A Longo; G Coruzzi; P Carminati
Journal:  Dig Dis Sci       Date:  1999-04       Impact factor: 3.199

  1 in total

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