Literature DB >> 1308068

[The experimental infection of Cebus apella sp. monkeys with Trypanosoma cruzi. Its clinical, electrocardiographic and anatomicopathological assessment].

E A de Almeida1, M R Navarro, M E Guariento, S dos S Carvalhal.   

Abstract

Thirty-two monkeys were captured and adapted to laboratory conditions captives isolated. They were submitted to multiple xenodiagnosis which were negative. Twelve were infected intraperitoneally with different strains of T. cruzi (1.10(5) to 5.10(6)). Twenty were the control group. Between on to six years both the control group and the infected monkeys, were submitted to xenodiagnosis, serological testing clinical examination and electrocardiography. The clinical examination and the electrocardiogram were always normal. The monkey were autopsied and histological examination detected in the infected group four monkeys with evidence of disease: one with parasites in the tissue and three with chronic myocarditis. Parasitaemia was in 66.66% of the monkeys in the acute phase and the serology was positive in 91.66% in the chronic phase. The authors concluded that Cebus monkeys were not susceptible to the development of the disease but they could be utilized to maintain of such strains and studies of serological research in long-terms infections.

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Year:  1992        PMID: 1308068     DOI: 10.1590/s0037-86821992000100002

Source DB:  PubMed          Journal:  Rev Soc Bras Med Trop        ISSN: 0037-8682            Impact factor:   1.581


  3 in total

1.  Advances in imaging of animal models of Chagas disease.

Authors:  Linda A Jelicks; Herbert B Tanowitz
Journal:  Adv Parasitol       Date:  2011       Impact factor: 3.870

Review 2.  Translational challenges of animal models in Chagas disease drug development: a review.

Authors:  Eric Chatelain; Nandini Konar
Journal:  Drug Des Devel Ther       Date:  2015-08-19       Impact factor: 4.162

3.  An Animal Model of Acute and Chronic Chagas Disease With the Reticulotropic Y Strain of Trypanosoma cruzi That Depicts the Multifunctionality and Dysfunctionality of T Cells.

Authors:  Jose Mateus; Paula Guerrero; Paola Lasso; Claudia Cuervo; John Mario González; Concepción J Puerta; Adriana Cuéllar
Journal:  Front Immunol       Date:  2019-04-26       Impact factor: 7.561

  3 in total

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