The effect of temperature on the growth of virus-induced frog carcinoma. II. The temperature coefficient of growth in vitro.

The temperature coefficient of van't Hoff, Q(10), for growth of frog carcinoma in vitro over a range of 20-35 degrees C, averages 2.5. This value is closely similar to those obtained for various forms of normal growth. The values of the temperature coefficient slightly but progressively decrease with advancing age of the cancer colonies. A similar relation obtains in many but not in all forms of normal growth. Thus, the law of van't Hoff is found to hold equally for growth of the malignant tissue now under discussion and for normal tissue.