Literature DB >> 1303726

Metabolic activation of phenols by stimulated neutrophils: a concept for a selective type of anti-inflammatory drug.

B A Hart1, J M Simons.   

Abstract

Apocynin (4-hydroxy-3-methoxy-acetophenone) is a potent and selective inhibitor of neutrophil oxyradical production. The mechanism of action involves metabolic activation in a (myelo)-peroxidase-dependent reaction. The reaction product(s) prevent(s) the assembly of the superoxide anion-generating NADPH:O2 oxidoreductase by conjugation to essential thiol groups. Different neutrophil functions that are essential to their bactericidal activity, however, remain intact. When administered orally a potent anti-inflammatory activity was found in rats with experimentally induced local or systemic inflammation.

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Year:  1992        PMID： 1303726

Source DB:  PubMed          Journal:  Biotechnol Ther        ISSN： 0898-2848


  12 in total

1.  Mechanisms of tumor necrosis factor-alpha-induced interleukin-6 synthesis in glioma cells.

Authors:  Kumiko Tanabe; Rie Matsushima-Nishiwaki; Shinobu Yamaguchi; Hiroki Iida; Shuji Dohi; Osamu Kozawa
Journal:  J Neuroinflammation       Date:  2010-03-06       Impact factor: 8.322

2.  Inhibition of NAD(P)H oxidase activity blocks vascular endothelial growth factor overexpression and neovascularization during ischemic retinopathy.

Authors:  Mohamed Al-Shabrawey; Manuela Bartoli; Azza B El-Remessy; Daniel H Platt; Sue Matragoon; M Ali Behzadian; Robert W Caldwell; Ruth B Caldwell
Journal:  Am J Pathol       Date:  2005-08       Impact factor: 4.307

3.  The Brucella abortus Cu,Zn superoxide dismutase is required for optimal resistance to oxidative killing by murine macrophages and wild-type virulence in experimentally infected mice.

Authors:  Jason M Gee; Michelle Wright Valderas; Michael E Kovach; Vanessa K Grippe; Gregory T Robertson; Wai-Leung Ng; John M Richardson; Malcolm E Winkler; R Martin Roop
Journal:  Infect Immun       Date:  2005-05       Impact factor: 3.441

4.  SodA is a major metabolic antioxidant in Brucella abortus 2308 that plays a significant, but limited, role in the virulence of this strain in the mouse model.

Authors:  Daniel W Martin; John E Baumgartner; Jason M Gee; Eric S Anderson; R Martin Roop
Journal:  Microbiology       Date:  2012-05-03       Impact factor: 2.777

5.  Periplasmic superoxide dismutase protects Salmonella from products of phagocyte NADPH-oxidase and nitric oxide synthase.

Authors:  M A De Groote; U A Ochsner; M U Shiloh; C Nathan; J M McCord; M C Dinauer; S J Libby; A Vazquez-Torres; Y Xu; F C Fang
Journal:  Proc Natl Acad Sci U S A       Date:  1997-12-09       Impact factor: 11.205

6.  Activated NAD(P)H oxidase from supplemental oxygen induces neovascularization independent of VEGF in retinopathy of prematurity model.

Authors:  Yuta Saito; Abhineet Uppal; Grace Byfield; Steven Budd; M Elizabeth Hartnett
Journal:  Invest Ophthalmol Vis Sci       Date:  2008-04       Impact factor: 4.799

7.  Regulation of swelling-activated Cl(-) current by angiotensin II signalling and NADPH oxidase in rabbit ventricle.

Authors:  Zuojun Ren; Frank J Raucci; David M Browe; Clive M Baumgarten
Journal:  Cardiovasc Res       Date:  2007-10-04       Impact factor: 10.787

8.  SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model.

Authors:  Maged M Harraz; Jennifer J Marden; Weihong Zhou; Yulong Zhang; Aislinn Williams; Victor S Sharov; Kathryn Nelson; Meihui Luo; Henry Paulson; Christian Schöneich; John F Engelhardt
Journal:  J Clin Invest       Date:  2008-02       Impact factor: 14.808

9.  Oral treatment with the NADPH oxidase antagonist apocynin mitigates clinical and pathological features of parkinsonism in the MPTP marmoset model.

Authors:  Ingrid H C H M Philippens; Jacqueline A Wubben; Bente Finsen; Bert A 't Hart
Journal:  J Neuroimmune Pharmacol       Date:  2013-03-17       Impact factor: 4.147

10.  Inhibition of NAD(P)H oxidase reduces apoptosis and avascular retina in an animal model of retinopathy of prematurity.

Authors:  Yuta Saito; Pete Geisen; Abhineet Uppal; M Elizabeth Hartnett
Journal:  Mol Vis       Date:  2007-06-12       Impact factor: 2.367
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