Literature DB >> 13022849

The inhibition by cortisone of the cytotoxic activity of PPD on tuberculin-hypersensitive cells in tissue culture.

R H LEAHY, H R MORGAN.   

Abstract

Using the roller tube method of tissue culture, it has been shown that cortisone and compound F inhibit the cytotoxic action of PPD upon macrophages from the splenic tissue of tuberculous guinea pigs. Pretreatment of the cells for 24 hours with hormones before exposure to PPD was found to be essential. Estrone and desoxycorticosterone glucoside had no protective activity. Certain advantages of the tissue culture method in studies of tuberculin hypersensitivity and possible mechanisms and implications of this protective action of cortisone are discussed.

Entities:  

Keywords:  CORTISONE/effects; TUBERCULIN

Mesh：

Substances：

Year:  1952        PMID： 13022849      PMCID： PMC2136171          DOI： 10.1084/jem.96.6.549

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  5 in total

1.  Relation of oxygen and temperature in the preservation of tissues by refrigeration.

Authors:  J H HANKS; R E WALLACE
Journal:  Proc Soc Exp Biol Med       Date:  1949-06

2.  The histology of the tuberculin reaction and its modification by cortisone.

Authors:  P G H GELL; I T HINDE
Journal:  Br J Exp Pathol       Date:  1951-12

3.  In vivo observations on the effect of cortisone on experimental tuberculosis, using the rabbit ear chamber technique.

Authors:  R H EBERT
Journal:  Am Rev Tuberc       Date:  1952-01

4.  Effect of cortisone on some reactions of hypersensitivity in laboratory animals.

Authors:  S HARRIS; T N HARRIS
Journal:  Proc Soc Exp Biol Med       Date:  1950-05

5.  The ability of ACTH and cortisone to alter delayed type bacterial hypersensitivity.

Authors:  J B LONG; C B FAVOUR
Journal:  Bull Johns Hopkins Hosp       Date:  1950-09
  5 in total
  11 in total

1.  Effect of cortisone on the growth of psittacosis virus in cultures of L cells.

Authors:  R B STEWART
Journal:  J Bacteriol       Date:  1960-07       Impact factor: 3.490

2.  Hydrocortisone and the migration of human leucocytes: an indirect effect mediated by mononuclear cells.

Authors:  R D Stevenson
Journal:  Clin Exp Immunol       Date:  1973-07       Impact factor: 4.330

3.  Studies on the production and action of polymorph migration stimulator.

Authors:  R D Stevenson
Journal:  Clin Exp Immunol       Date:  1976-06       Impact factor: 4.330

4.  The pyrogenic effect of scarlet fever toxin. 3. The effect of cortisone on the pyrogenic, lethal and dermal activity of scarlet fever toxin.

Authors:  V Hríbalová; V Schuh
Journal:  Folia Microbiol (Praha)       Date:  1967       Impact factor: 2.099

5.  Methylprednisolone inhibits the alternative and amplification pathways of complement.

Authors:  J M Weiler; B D Packard
Journal:  Infect Immun       Date:  1982-10       Impact factor: 3.441

6.  Studies on the pathogenesis of acute inflammation. II. The action of cortisone on the inflammatory response to thermal injury.

Authors:  F ALLISON; M R SMITH; W B WOOD
Journal:  J Exp Med       Date:  1955-12-01       Impact factor: 14.307

7.  The in vitro action of hydrocortisone on leucocyte migration.

Authors:  M M KETCHEL; C B FAVOUR; S H STURGIS
Journal:  J Exp Med       Date:  1958-02-01       Impact factor: 14.307

8.  Studies on hypersensitivity of human tissues in vitro. I. Tuberculin hypersensitivity.

Authors:  E J GANGAROSA; J T INGLEFIELD; C G THOMAS; H R MORGAN
Journal:  J Exp Med       Date:  1955-10-01       Impact factor: 14.307

9.  The effect of tuberculin and cortisone singly and in combination on explanted tissues of guinea pigs, mice and rabbits.

Authors:  M HOLDEN; B C SEEGAL; L B ADAMS
Journal:  J Exp Med       Date:  1953-12       Impact factor: 14.307

10.  Inhibition of red cell sequestration by cortisone.

Authors:  M E KAPLAN; J H JANDL
Journal:  J Exp Med       Date:  1961-12-01       Impact factor: 14.307
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.