| Literature DB >> 1301999 |
E J Neufeld1, D G Skalnik, P M Lievens, S H Orkin.
Abstract
Human CCAAT displacement protein (CDP), a putative repressor of developmentally regulated gene expression, was purified from HeLa cells by DNA binding-site affinity chromatography. cDNA encoding CDP was obtained by immunoscreening a lambda gt11 library with antibody raised against purified protein. The deduced primary amino acid sequence of CDP reveals remarkable homology to Drosophila cut with respect to the presence of a unique homeodomain and "cut repeats". As cut participates in determination of cell fate in several tissues in Drosophila, the similarity predicts a broad role for CDP in mammalian development.Entities:
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Year: 1992 PMID： 1301999 DOI： 10.1038/ng0492-50
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330