| Literature DB >> 1301351 |
V Lukić1, A Husek, O Gasić, D Walterova, V Simanek.
Abstract
The major pathway of metabolic transformation of N-deacetyl-N-formylcolchicine is the oxidative cytochrome P450 dependent O-demethylation of substituents in the aromatic ring A and tropolone ring C. It was found that O-demethylation (both, in vitro and in vivo) takes place predominantly in the aromatic ring, especially at position 2.Entities:
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Year: 1992 PMID： 1301351 DOI： 10.1007/BF03190154
Source DB: PubMed Journal: Eur J Drug Metab Pharmacokinet ISSN： 0378-7966 Impact factor: 2.441