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Literature DB >> 13009518

Chemical agents in neoplastic diseases; an evaluation of chemotherapeutic substances for clinical management.

Abstract

The rapid appearance of many new chemical substances which possess some antineoplastic effects has created a complex problem for the practicing physician. These agents which have shown promise in man and lower animals are grouped according to their modes of action. Each substance is discussed thoroughly with regard to its structure, activity, and influence upon the neoplasms of man. Key references are cited, and the practical value of each chemical agent is defined. The proper methods of administration of the compounds recommended for use are carefully described. In addition a section on agents whose therapeutic value has been disproven is also included.

Entities: Disease Species

Keywords: NEOPLASMS/therapy

Mesh：

Substances：
Antineoplastic Agents

Year: 1953 PMID： 13009518 PMCID： PMC1521576

Source DB: PubMed Journal: Calif Med ISSN： 0008-1264

64 in total

1. The effect of cortisone in Hodgkin's disease.

Authors: B STRAUS; A S JACOBSON; S A BERSON; T C BERNSTEIN; R S FADEM; R S YALOW
Journal: Am J Med Date: 1952-02 Impact factor: 4.965

2. Effect of 2-chloro-2'-hydroxydiethyl sulfide (hemisulfur mustard) on carcinomatosis with ascites.

Authors: A M SELIGMAN; A M RUTENBERG; L PERSKY; O M FRIEDMAN
Journal: Cancer Date: 1952-03 Impact factor: 6.860

3. Triethylene melamine in the treatment of neoplastic disease.

Authors: R W RUNDLES; W B BARTON
Journal: Blood Date: 1952-05 Impact factor: 22.113

4. Studies on the mechanism of action of chemotherapeutic agents in cancer. VI. Synergistic (additive) action of drugs on a transplantable leukemia in mice.

Authors: A GOLDIN; E M GREENSPAN; E B SCHOENBACH
Journal: Cancer Date: 1952-01 Impact factor: 6.860

5. The rationale and clinical use of steroid hormones in cancer.

Authors: S I GRIBOFF
Journal: AMA Arch Intern Med Date: 1952-05

6. Triethylene melamine in the treatment of neoplastic disease; a compound with nitrogen-mustardlike activity suitable for oral and intravenous use.

Authors: D A KARNOFSKY; J H BURCHENAL; G C ARMISTEAD; C M SOUTHAM; J L BERNSTEIN; L F CRAVER; C P RHOADS
Journal: AMA Arch Intern Med Date: 1951-04

Chemical agents in neoplastic diseases; an evaluation of chemotherapeutic substances for clinical management.

1. The effect of cortisone in Hodgkin's disease.

2. Effect of 2-chloro-2'-hydroxydiethyl sulfide (hemisulfur mustard) on carcinomatosis with ascites.

3. Triethylene melamine in the treatment of neoplastic disease.

4. Studies on the mechanism of action of chemotherapeutic agents in cancer. VI. Synergistic (additive) action of drugs on a transplantable leukemia in mice.

5. The rationale and clinical use of steroid hormones in cancer.

6. Triethylene melamine in the treatment of neoplastic disease; a compound with nitrogen-mustardlike activity suitable for oral and intravenous use.

7. The nitrogen mustard-like actions of 2,4,6-tris (ethylenimino)-s-triazine and other bis(ethylenimines).

8. The effect of transfusions and antibiotics upon the duration of life in children with lymphogenous leucemia.

9. Preliminary studies on the clinical toxicity of 5-amino-7-hydroxy-1-v-triazolo[d]-pyrimidine.

10. Observations on the physiologic effects of cortisone and ACTH in man.

1. [Long-term chemotherapy of chronic myeloid leukemia with Myleran and C69].